ArticleThe American journal of pathology2010
Experimental neonatal status epilepticus and the development of temporal lobe epilepsy with unilateral hippocampal sclerosis.
Article in The American journal of pathology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Intestinal microbiome alterations in pediatric epilepsy: Implications for seizures and therapeutic approaches.Epilepsia open · 2025Article
- WONOEP appraisal: Modeling early onset epilepsies.Epilepsia · 2024Review
- Riluzole and novel naphthalenyl substituted aminothiazole derivatives prevent acute neural excitotoxic injury in a rat model of temporal lobe epilepsy.Neuropharmacology · 2023Article
- Narrative review of epilepsy: getting the most out of your neuroimaging.Translational pediatrics · 2021Review
- Ripple-related firing of identified deep CA1 pyramidal cells in chronic temporal lobe epilepsy in mice.Epilepsia open · 2019Article
- Ghrelin improves pilocarpine‑induced cerebral cortex inflammation in epileptic rats by inhibiting NF‑κB and TNF‑α.Molecular medicine reports · 2018Article
- Article
- Sex-specific consequences of early life seizures.Neurobiology of disease · 2014Review
- A novel, noninvasive, predictive epilepsy biomarker with clinical potential.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- P2X7 receptor inhibition interrupts the progression of seizures in immature rats and reduces hippocampal damage.CNS neuroscience & therapeutics · 2014Article
- Neurogenic function in rats with unilateral hippocampal sclerosis that experienced early-life status epilepticus.International journal of physiology, pathophysiology and pharmacology · 2014Article
- The kainic acid model of temporal lobe epilepsy.Neuroscience and biobehavioral reviews · 2013Review
- Hippocampal body changes in pure partial onset sleep and pure partial onset waking epileptic patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- The cellular and synaptic location of activated TrkB in mouse hippocampus during limbic epileptogenesis.The Journal of comparative neurology · 2013Article
- Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.PloS one · 2013Article
- Neonatal encephalopathy, MRI lesions, and later epilepsy: no harm, no foul?Epilepsy currents · 2012Article
- Article
- Hippocampal sclerosis in children younger than 2 years.Pediatric radiology · 2011Article
- Lessons from the laboratory: the pathophysiology, and consequences of status epilepticus.Seminars in pediatric neurology · 2010Review
- Status Epilepticus in Neonates and Infants.Annals of Indian Academy of NeurologyReview
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Hippocampal sclerosis is a common pathological finding in patients with temporal lobe epilepsy, including children, but a causal relationship to early-life seizures remains in question. Neonatal status epilepticus in animals can result in neuronal death within the hippocampus, although macroscopic features of hippocampal shrinkage are not evident at adulthood. Here, we examined electrophysiological and pathological consequences of focally evoked status epilepticus triggered by intra-amygdala microinjection of kainic acid in postnatal day 10 rat pups. Neonatal status epilepticus resulted in extensive neuronal death in the ipsilateral hippocampal CA1 and CA3 subfields and hilus, as assessed by DNA fragmentation and Fluoro-Jade B staining 72 hours later. The contralateral hippocampus was not significantly damaged. Histopathology at P55/P65 revealed unilateral hippocampal sclerosis (grade IV, modified Wyler/Watson scale) comprising >50% CA1 and CA3 neuron loss and astrogliosis. Additional features included hydrocephalus ex vacuo, modest dentate granule cell layer widening, and altered neuropeptide Y immunoreactivity indicative of synaptic rearrangement. Hippocampal atrophy was also evident on magnetic resonance imaging. Depth electrode recordings at adulthood detected spontaneous seizures that involved the ipsilateral hippocampus and amygdala. A significant positive correlation was found between hippocampal pathology grade and both frequency and duration of epileptic seizures at adulthood. The current study demonstrates that experimental neonatal status epilepticus can result in classical unilateral hippocampal sclerosis and temporal lobe epilepsy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.