ArticleThe Journal of cell biology2009
delta-EF1 is a negative regulator of Ihh in the developing growth plate.
Article in The Journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Differential regulation of coronal and lambdoid suture patency by PTHLH and HHIP activity in mice.Development (Cambridge, England) · 2025Article
- A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling.The EMBO journal · 2023Article
- An "unexpected" role for EMT transcription factors in hematological development and malignancy.Frontiers in immunology · 2023Review
- Pancreas morphogenesis and homeostasis depends on tightly regulated Zeb1 levels in epithelial cells.Cell death discovery · 2021Article
- Article
- Zeb1-Hdac2-eNOS circuitry identifies early cardiovascular precursors in naive mouse embryonic stem cells.Nature communications · 2018Article
- The zinc finger E-box-binding homeobox 1 (The Journal of biological chemistry · 2017Article
- Computer simulation models as a tool to investigate the role of microRNAs in osteoarthritis.PloS one · 2017Article
- Developmental Regulation of the Growth Plate and Cranial Synchondrosis.Journal of dental research · 2016Review
- A Qualitative Model of the Differentiation Network in Chondrocyte Maturation: A Holistic View of Chondrocyte Hypertrophy.PloS one · 2016Article
- Multifaceted signaling regulators of chondrogenesis: Implications in cartilage regeneration and tissue engineering.Genes & diseases · 2015Article
- High-resolution association mapping of number of teats in pigs reveals regions controlling vertebral development.BMC genomics · 2014Article
- Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling.Scientific reports · 2013Article
- δEF1 down-regulates ER-α expression and confers tamoxifen resistance in breast cancer.PloS one · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Indian hedgehog (Ihh) regulates proliferation and differentiation of chondrocytes in the growth plate. Although the biology of Ihh is currently well documented, its transcriptional regulation is poorly understood. delta-EF1 is a two-handed zinc finger/homeodomain transcriptional repressor. Targeted inactivation of mouse delta-EF1 leads to skeletal abnormalities including disorganized growth plates, shortening of long bones, and joint fusions, which are reminiscent of defects associated with deregulation of Ihh signaling. Here, we show that the absence of delta-EF1 results in delayed hypertrophic differentiation of chondrocytes and increased cell proliferation in the growth plate. Further, we demonstrate that delta-EF1 binds to the putative regulatory elements in intron 1 of Ihh in vitro and in vivo, resulting in down-regulation of Ihh expression. Finally, we show that delta-EF1 haploinsufficiency leads to a postnatal increase in trabecular bone mass associated with enhanced Ihh expression. In summary, we have identified delta-EF1 as an in vivo negative regulator of Ihh expression in the growth plate.
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