ArticleThe Journal of cell biology2009
Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1.
Article in The Journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 53 citations in OpenAlex.
- Notch3 is an asymmetric gene and a modifier of heart looping defects in Nodal mouse mutants.PLoS biology · 2025Article
- Nodal and cripto-1: distinct functions regulate trophoblast specification in mouse pregnancy.Frontiers in cell and developmental biology · 2025Article
- Knockdown of the prognostic cancer stem cell marker Musashi-1 decreases radio-resistance while enhancing apoptosis in hormone receptor-positive breast cancer cells via p21Journal of cancer research and clinical oncology · 2021Article
- GAS1 is required for NOTCH-dependent facilitation of SHH signaling in the ventral forebrain neuroepithelium.Development (Cambridge, England) · 2021Article
- Whence CRIPTO: The Reemergence of an Oncofetal Factor in 'Wounds' That Fail to Heal.International journal of molecular sciences · 2021Review
- The developmental origins of Notch-driven intrahepatic bile duct disorders.Disease models & mechanisms · 2021Article
- Maternal Cripto is required for proper uterine decidualization and peri-implantation uterine remodeling.Biology of reproduction · 2021Article
- Krabbe disease: New hope for an old disease.Neuroscience letters · 2021Review
- Exosomal Cripto-1 Serves as a Potential Biomarker for Perihilar Cholangiocarcinoma.Frontiers in oncology · 2021Article
- CRIPTO antagonist ALK4Breast cancer research : BCR · 2020Article
- Review
- Glucocorticoid receptor-dependent induction ofToxicology reports · 2019Article
- Notch Signaling Activation as a Hallmark for Triple-Negative Breast Cancer Subtype.Journal of oncology · 2019Review
- The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt.eLife · 2018Article
- Folate action in nervous system development and disease.Developmental neurobiology · 2018Review
- Biological and Clinicopathological Significance of Cripto-1 Expression in the Progression of Human ESCC.Reports of biochemistry & molecular biology · 2017Article
- Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi.Oncology letters · 2016Article
- Cripto-1 vaccination elicits protective immunity against metastatic melanoma.Oncoimmunology · 2016Article
- Developmental signaling pathways regulating mammary stem cells and contributing to the etiology of triple-negative breast cancer.Breast cancer research and treatment · 2016Review
- Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Nodal and Notch signaling pathways play essential roles in vertebrate development. Through a yeast two-hybrid screening, we identified Notch3 as a candidate binding partner of the Nodal coreceptor Cripto-1. Coimmunoprecipitation analysis confirmed the binding of Cripto-1 with all four mammalian Notch receptors. Deletion analyses revealed that the binding of Cripto-1 and Notch1 is mediated by the Cripto-1/FRL-1/Cryptic domain of Cripto-1 and the C-terminal region of epidermal growth factor-like repeats of Notch1. Binding of Cripto-1 to Notch1 occurred mainly in the endoplasmic reticulum-Golgi network. Cripto-1 expression resulted in the recruitment of Notch1 protein into lipid raft microdomains and enhancement of the furin-like protein convertase-mediated proteolytic maturation of Notch1 (S1 cleavage). Enhanced S1 cleavage resulted in the sensitization to ligand-induced activation of Notch signaling. In addition, knockdown of Cripto-1 expression in human and mouse embryonal carcinoma cells desensitized the ligand-induced Notch signaling activation. These results suggest a novel role of Cripto-1 in facilitating the posttranslational maturation of Notch receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.