ArticleThe Journal of cell biology2009
{gamma}-Tubulin ring complexes regulate microtubule plus end dynamics.
Article in The Journal of cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed.
- Multifaceted modes of γ-tubulin complex recruitment and microtubule nucleation at mitotic centrosomes.The Journal of cell biology · 2023Article
- γ-Tubulin in microtubule nucleation and beyond.Frontiers in cell and developmental biology · 2022Review
- Review
- The cryo-EM structure of a γ-TuSC elucidates architecture and regulation of minimal microtubule nucleation systems.Nature communications · 2020Article
- Roles of end-binding 1 protein and gamma-tubulin small complex in cytokinesis and flagella formation of Giardia lamblia.MicrobiologyOpen · 2019Article
- TUBG1 missense variants underlying cortical malformations disrupt neuronal locomotion and microtubule dynamics but not neurogenesis.Nature communications · 2019Article
- Microtubule nucleation by γ-tubulin complexes and beyond.Essays in biochemistry · 2018Review
- Differential regulation of transition zone and centriole proteins contributes to ciliary base diversity.Nature cell biology · 2018Article
- Profilin connects actin assembly with microtubule dynamics.Molecular biology of the cell · 2016Article
- Characterization of Adenomatous Polyposis Coli Protein Dynamics and Localization at the Centrosome.Cancers · 2016Article
- The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle.Nature communications · 2015Article
- γ-Tubulin complexes in microtubule nucleation and beyond.Molecular biology of the cell · 2015Article
- Centrosome age regulates kinetochore-microtubule stability and biases chromosome mis-segregation.eLife · 2015Article
- Mutations in TUBGCP4 alter microtubule organization via the γ-tubulin ring complex in autosomal-recessive microcephaly with chorioretinopathy.American journal of human genetics · 2015Article
- Article
- γ-Tubulin Ring Complexes and EB1 play antagonistic roles in microtubule dynamics and spindle positioning.The EMBO journal · 2014Article
- Short-circuiting microtubule plus and minus end proteins in spindle positioning.The EMBO journal · 2014Article
- Fission yeast MOZART1/Mzt1 is an essential γ-tubulin complex component required for complex recruitment to the microtubule organizing center, but not its assembly.Molecular biology of the cell · 2013Article
- Microtubule catastrophe and rescue.Current opinion in cell biology · 2013Review
- Calcium-binding capacity of centrin2 is required for linear POC5 assembly but not for nucleotide excision repair.PloS one · 2013Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
gamma-Tubulin is critical for the initiation and regulation of microtubule (MT) assembly. In Drosophila melanogaster, it acts within two main complexes: the gamma-tubulin small complex (gamma-TuSC) and the gamma-tubulin ring complex (gamma-TuRC). Proteins specific of the gamma-TuRC, although nonessential for viability, are required for efficient mitotic progression. Until now, their role during interphase remained poorly understood. Using RNA interference in Drosophila S2 cells, we show that the gamma-TuRC is not critical for overall MT organization. However, depletion of any component of this complex results in an increase of MT dynamics. Combined immunofluorescence and live imaging analysis allows us to reveal that the gamma-TuRC localizes along interphase MTs and that distal gamma-tubulin spots match with sites of pause or rescue events. We propose that, in addition to its role in nucleation, the gamma-TuRC associated to MTs may regulate their dynamics by limiting catastrophes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.