ReviewBrain research2010
The role of hypocretin in driving arousal and goal-oriented behaviors.
Review in Brain research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 128 citations in OpenAlex.
- The Relationship between Alcohol Craving and Insomnia Symptoms in Alcohol-Dependent Individuals.Alcohol and alcoholism (Oxford, Oxfordshire) · 2019Trial
- Trial
- Orexins and neuregulins as exemplars of peptide physiology in the brain: experimental challenges and implications for neuropathology.Frontiers in cellular neuroscience · 2026Article
- Inactivation of hypocretin receptor-2 signaling in dopaminergic neurons induces hyperarousal and enhanced cognition but impaired inhibitory control.Molecular psychiatry · 2024Article
- Improvement of autistic-like behaviors in adult rats prenatally exposed to valproic acid through early suppression of orexin receptor.Annals of medicine and surgery (2012) · 2024Article
- Cross-talk between the HPA axis and addiction-related regions in stressful situations.Heliyon · 2023Review
- Optogenetic and pharmacological interventions link hypocretin neurons to impulsivity in mice.Communications biology · 2023Article
- Age-specific treatment effects of orexin/hypocretin-receptor antagonism on methamphetamine-seeking behavior.Drug and alcohol dependence · 2021Article
- Ontogeny of the Projections From the Dorsomedial Division of the Anterior Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei.Frontiers in neuroscience · 2021Article
- Article
- The Paraventricular Nucleus of the Thalamus as an Integrating and Relay Node in the Brain Anxiety Network.Frontiers in behavioral neuroscience · 2021Review
- Involvement of orexin/hypocretin in the expression of social play behaviour in juvenile rats.International journal of play · 2020Article
- Keel Fracture Causes Stress and Inflammatory Responses and Inhibits the Expression of the Orexin System in Laying Hens.Animals : an open access journal from MDPI · 2019Article
- Application of Research Domain Criteria to childhood and adolescent impulsive and addictive disorders: Implications for treatment.Clinical psychology review · 2018Review
- Lateral Hypothalamus as a Motivation-Cognition Interface in the Control of Feeding Behavior.Frontiers in systems neuroscience · 2018Review
- Recent advances in understanding the roles of hypocretin/orexin in arousal, affect, and motivation.F1000Research · 2018Review
- Multiple excitatory actions of orexins upon thalamo-cortical neurons in dorsal lateral geniculate nucleus - implications for vision modulation by arousal.Scientific reports · 2017Article
- Neuroclinical Framework for the Role of Stress in Addiction.Chronic stress (Thousand Oaks, Calif.) · 2017Article
- A Decade of Orexin/Hypocretin and Addiction: Where Are We Now?Current topics in behavioral neurosciences · 2017Review
- Different Molecular/Behavioral Endophenotypes in C57BL/6J Mice Predict the Impact of OXFrontiers in behavioral neuroscience · 2017Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The hypocretins (Hcrts), also called orexins, are two neuropeptides secreted by a few thousand neurons restricted to the lateral hypothalamus. The Hcrt peptides bind to two receptors located in nuclei associated with diverse cognitive and physiological functions. Experimental evidence has demonstrated that the physiological roles of hypocretins extend far beyond its initial role in food consumption and has emerged as a key system in the fields of sleep disorders and drug addiction. Here, we discuss recent evidence demonstrating a key role of hypocretin in the motivation for reward seeking in general, and drug taking in particular, and we delineate a physiological framework for this peptidergic system in orchestrating the appropriate levels of alertness required for the elaboration and the execution of goal-oriented behaviors. We propose a general role for hypocretins in mediating arousal, especially when an organism must respond to unexpected stressors and environmental challenges, which serve to shape survival behaviors. We also discuss the limit of the current experimental paradigms to address the question of how a system normally involved in the regulation of vigilance states and hyperarousal may promote a pathological state that elicits compulsive craving and relapse to drug seeking.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.