ArticleBiophysical journal2009
Membrane curvature induced by aggregates of LH2s and monomeric LH1s.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Macroscale optimal size of ICM vesicles regulated by quantum design principle in LH2 structure.Biophysical journal · 2025Article
- Inducible intracellular membranes: molecular aspects and emerging applications.Microbial cell factories · 2020Review
- Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.Chemical reviews · 2019Review
- Membrane remodelling in bacteria.Journal of structural biology · 2016Review
- Article
- Light harvesting by lamellar chromatophores in Rhodospirillum photometricum.Biophysical journal · 2014Article
- Variation in supramolecular organisation of the photosynthetic membrane of Rhodobacter sphaeroides induced by alteration of PufX.Photosynthesis research · 2014Article
- Detection, characterization, and biological effect of quorum-sensing signaling molecules in peanut-nodulating bradyrhizobia.Sensors (Basel, Switzerland) · 2012Article
- Applications of the molecular dynamics flexible fitting method.Journal of structural biology · 2011Article
- Förster energy transfer theory as reflected in the structures of photosynthetic light-harvesting systems.Chemphyschem : a European journal of chemical physics and physical chemistry · 2011Review
- Bridging the gap: linking molecular simulations and systemic descriptions of cellular compartments.PloS one · 2010Article
- Minimal mesoscale model for protein-mediated vesiculation in clathrin-dependent endocytosis.PLoS computational biology · 2010Article
- Self-assembly of photosynthetic membranes.Chemphyschem : a European journal of chemical physics and physical chemistry · 2010Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The photosynthetic apparatus of purple bacteria is contained within organelles called chromatophores, which form as extensions of the cytoplasmic membrane. The shape of these chromatophores can be spherical (as in Rhodobacter sphaeroides), lamellar (as in Rhodopseudomonas acidophila and Phaeospirillum molischianum), or tubular (as in certain Rb. sphaeroides mutants). Chromatophore shape is thought to be influenced by the integral membrane proteins Light Harvesting Complexes I and II (LH1 and LH2), which pack tightly together in the chromatophore. It has been suggested that the shape of LH2, together with its close packing in the membrane, induces membrane curvature. The mechanism of LH2-induced curvature is explored via molecular dynamics simulations of multiple LH2 complexes in a membrane patch. LH2s from three species-Rb. sphaeroides, Rps. acidophila, and Phsp. molischianum-were simulated in different packing arrangements. In each case, the LH2s pack together and tilt with respect to neighboring LH2s in a way that produces an overall curvature. This curvature appears to be driven by a combination of LH2's shape and electrostatic forces that are modulated by the presence of well-conserved cytoplasmic charged residues, the removal of which inhibits LH2 curvature. The interaction of LH2s and an LH1 monomer is also explored, and it suggests that curvature is diminished by the presence of LH1 monomers. The implications of our results for chromatophore shape are discussed.
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