ArticleBiophysical journal2009
Simulation of cyclic dynein-driven sliding, splitting, and reassociation in an outer doublet pair.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Structure of Motile Cilia.Sub-cellular biochemistry · 2022Article
- Active beating modes of two clamped filaments driven by molecular motors.Journal of the Royal Society, Interface · 2022Article
- A computational model of dynein activation patterns that can explain nodal cilia rotation.Biophysical journal · 2015Article
- Engaging the "clutch" to move forward.Biophysical journal · 2014Article
- Dynein regulation: going into circles can set things straight.Biophysical journal · 2014Article
- Emergence of polar order and cooperativity in hydrodynamically coupled model cilia.Journal of the Royal Society, Interface · 2013Article
- The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes.Molecular biology of the cell · 2013Article
- bop5 Mutations reveal new roles for the IC138 phosphoprotein in the regulation of flagellar motility and asymmetric waveforms.Molecular biology of the cell · 2011Article
- Heart of the beat (the flagellar beat, that is).Biophysical journal · 2009Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
A regular cycle of dynein-driven sliding, doublet separation, doublet reassociation, and resumption of sliding was previously observed by Aoyama and Kamiya in outer doublet pairs obtained after partial dissociation of Chlamydomonas flagella. In the work presented here, computer programming based on previous simulations of oscillatory bending of microtubules was extended to simulate the cycle of events observed with doublet pairs. These simulations confirm the straightforward explanation of this oscillation by inactivation of dynein when doublets separate and resumption of dynein activity after reassociation. Reassociation is augmented by a dynein-dependent "adhesive force" between the doublets. The simulations used a simple mathematical model to generate velocity-dependent shear force, and an independent elastic model for adhesive force. Realistic results were obtained with a maximum adhesive force that was 36% of the maximum shear force. Separation between a pair of doublets is the result of a buckling instability that also initiates a period of uniform sliding that enlarges the separation. A similar instability may trigger sliding initiation events in flagellar bending cycles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.