ArticleBiophysical journal2009
Asymmetric oxidation of giant vesicles triggers curvature-associated shape transition and permeabilization.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 86 citations in OpenAlex.
- Rethinking photosensitization in therapy and sun protection.Chemical science · 2026Review
- Aging at the Crossroads of Cuproptosis and Ferroptosis: From Molecular Pathways to Age-Related Pathologies and Therapeutic Perspectives.International journal of molecular sciences · 2026Review
- Photoswitchable Molecular Motor Phospholipid: Synthesis, Characterization, and Integration into Lipid Vesicles.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Curvature-Assisted Vesicle Explosion Under Light-Induced Asymmetric Oxidation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Bioprinting of Synthetic Cell-like Lipid Vesicles to Augment the Functionality of Tissues after Manufacturing.ACS synthetic biology · 2024Article
- Triacylglycerol-droplet-induced bilayer spontaneous curvature in giant unilamellar vesicles.Biophysical journal · 2024Article
- Utilizing Extracellular Vesicles for Eliminating 'Unwanted Molecules': Harnessing Nature's Structures in Modern Therapeutic Strategies.Molecules (Basel, Switzerland) · 2024Review
- Two separate mechanisms are involved in membrane permeabilization during lipid oxidation.Biophysical journal · 2023Article
- Dynamics of mitochondrial membranes under photo-oxidative stress with high spatiotemporal resolution.Frontiers in cell and developmental biology · 2023Article
- Use of giant unilamellar lipid vesicles as antioxidant carriers in in vitro culture medium of bovine embryos.Scientific reports · 2022Article
- Shape Deformation, Budding and Division of Giant Vesicles and Artificial Cells: A Review.Life (Basel, Switzerland) · 2022Review
- MEMBRANE PROTEIN STRUCTURES AND INTERACTIONS FROM COVALENT LABELING COUPLED WITH MASS SPECTROMETRY.Mass spectrometry reviews · 2022Review
- Article
- Light-Triggered Cargo Loading and Division of DNA-Containing Giant Unilamellar Lipid Vesicles.Nano letters · 2021Article
- The antioxidant vitamin E as a membrane raft modulator: Tocopherols do not abolish lipid domains.Biochimica et biophysica acta. Biomembranes · 2020Article
- PIP2 Reshapes Membranes through Asymmetric Desorption.Biophysical journal · 2019Article
- Redox (phospho)lipidomics of signaling in inflammation and programmed cell death.Journal of leukocyte biology · 2019Review
- Lipid Unsaturation Properties Govern the Sensitivity of Membranes to Photoinduced Oxidative Stress.Biophysical journal · 2019Article
- Extracellular Vesicles Released by Cardiomyocytes in a Doxorubicin-Induced Cardiac Injury Mouse Model Contain Protein Biomarkers of Early Cardiac Injury.Clinical cancer research : an official journal of the American Association for Cancer Research · 2018Article
- Chemotherapy-Induced Tissue Injury: An Insight into the Role of Extracellular Vesicles-Mediated Oxidative Stress Responses.Antioxidants (Basel, Switzerland) · 2017Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidation of unsaturated lipids is a fundamental process involved in cell bioenergetics as well as in cell death. Using giant unilamellar vesicles and a chlorin photosensitizer, we asymmetrically oxidized the outer or inner monolayers of lipid membranes. We observed different shape transitions such as oblate to prolate and budding, which are typical of membrane curvature modifications. The asymmetry of the shape transitions is in accordance with a lowered effective spontaneous curvature of the leaflet being targeted. We interpret this effect as a decrease in the preferred area of the targeted leaflet compared to the other, due to the secondary products of oxidation (cleaved-lipids). Permeabilization of giant vesicles by light-induced oxidation is observed after a lag and is characterized in relation with the photosensitizer concentration. We interpret permeabilization as the opening of a pore above a critical membrane tension, resulting from the budding of vesicles. The evolution of photosensitized giant vesicle lysis tension was measured and yields an estimation of the effective spontaneous curvature at lysis. Additionally photo-oxidation was shown to be fusogenic.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.