ArticleJournal of occupational medicine and toxicology (London, England)2009
Evaluation of the tuberculin skin test and the interferon-gamma release assay for TB screening in French healthcare workers.
Article in Journal of occupational medicine and toxicology (London, England), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Risk of Occupational Latent Tuberculosis Infection among Health Personnel Measured by Interferon-Gamma Release Assays in Low Incidence Countries-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Article
- Interferon-gamma release assay for the diagnosis of latent tuberculosis infection: A latent-class analysis.PloS one · 2017Article
- Prevalence of latent tuberculosis infection in healthcare workers at a hospital in Naples, Italy, a low-incidence country.Journal of occupational medicine and toxicology (London, England) · 2016Article
- Comparison of the tuberculin skin test and the QuantiFERON-TB Gold test in detecting latent tuberculosis in health care workers in Iran.Epidemiology and health · 2016Article
- Tuberculin skin test and Quantiferon test agreement and influencing factors in tuberculosis screening of healthcare workers: a systematic review and meta-analysis.Journal of occupational medicine and toxicology (London, England) · 2015Article
- Tuberculosis in healthcare workers - a narrative review from a German perspective.Journal of occupational medicine and toxicology (London, England) · 2014Article
- Tuberculosis screening at the Sainte-Anne Hospital in Paris - results of first and second IGRA.Journal of occupational medicine and toxicology (London, England) · 2014Article
- Latent tuberculosis in healthcare workers: time to act.Oman medical journal · 2013Article
- Screening for tuberculosis and the use of a borderline zone for the interpretation of the interferon-γ release assay (IGRA) in Portuguese healthcare workers.Journal of occupational medicine and toxicology (London, England) · 2013Article
- Interferon-Gamma Release Assays versus Tuberculin Skin Testing for the Diagnosis of Latent Tuberculosis Infection: An Overview of the Evidence.Pulmonary medicine · 2013Article
- The effect of introducing IGRA to screen French healthcare workers for tuberculosis and potential conclusions for the work organisation.Journal of occupational medicine and toxicology (London, England) · 2013Article
- Infectious diseases in healthcare workers - an analysis of the standardised data set of a German compensation board.Journal of occupational medicine and toxicology (London, England) · 2012Article
- Screening for tuberculosis and prediction of disease in Portuguese healthcare workers.Journal of occupational medicine and toxicology (London, England) · 2011Article
- Tuberculosis infection among homeless persons and caregivers in a high-tuberculosis-prevalence area in Japan: a cross-sectional study.BMC infectious diseases · 2011Article
- Results of five-year systematic screening for latent tuberculosis infection in healthcare workers in Portugal.Journal of occupational medicine and toxicology (London, England) · 2010Article
- Risk of latent TB infection in individuals employed in the healthcare sector in Germany: a multicentre prevalence study.BMC infectious diseases · 2010Article
- Screening for Latent Tuberculosis among Healthcare Workers in an Egyptian Hospital Using Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube Test.Indian journal of occupational and environmental medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionUsing French cut-offs for the Tuberculin Skin Test (TST), results of the TST were compared with the results of an Interferon-gamma Release Assay (IGRA) in Healthcare Workers (HCW) after contact to AFB-positive TB patients.
methodsBetween May 2006 and May 2007, a total of 148 HCWs of the University Hospital in Nantes, France were tested simultaneously with IGRA und TST. A TST was considered to indicate recent latent TB infection (LTBI) if an increase of >10 mm or if TST >/= 15 mm for those with no previous TST result was observed. For those with a positive TST, chest X-ray was performed and preventive chemotherapy was offered.
resultsAll HCWs were BCG-vaccinated. The IGRA was positive in 18.9% and TST >/= 10 mm was observed in 65.5%. A recent LTBI was believed to be highly probable in 30.4% following TST. Agreement between IGRA and TST was low (kappa 0.041). In 10 (16.7%) out of 60 HCWs who needed chest X-ray following TST the IGRA was positive. In 9 (20%) out of 45 HCWs to whom preventive chemotherapy was offered following TST the IGRA was positive. Of those considered TST-negative following the French guidelines, 20.5% were IGRA-positive. In a two-step strategy - positive TST verified by IGRA - 18 out of 28 (64.3%) IGRA-positive HCWs would not have been detected using French guidelines for TST interpretation.
conclusionThe introduction of IGRA in contact tracings of BCG-vaccinated HCWs reduces X-rays and preventive chemotherapies. Increasing the cut-off for a positive TST does not seem to be helpful to overcome the effect of BCG vaccination on TST.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.