ArticleJournal of the American Chemical Society2009
Loop and backbone modifications of peptide nucleic acid improve g-quadruplex binding selectivity.
Article in Journal of the American Chemical Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- PNA-ligand conjugates enable site-selective and directional targeting of adjacent G-quadruplexes.Chemical science · 2026Article
- Applications of Surface Plasmon Resonance for Advanced Studies Involving Nucleic Acids.RNA nanomed · 2024Article
- Quadruplex-duplex junction in LTR-III: A molecular insight into the complexes with BMH-21, namitecan and doxorubicin.PloS one · 2024Article
- Perspectives on conformationally constrained peptide nucleic acid (PNA): insights into the structural design, properties and applications.RSC chemical biology · 2022Review
- Beyond small molecules: targeting G-quadruplex structures with oligonucleotides and their analogues.Nucleic acids research · 2021Review
- From Prebiotic Chemistry to Supramolecular Biomedical Materials: Exploring the Properties of Self-Assembling Nucleobase-Containing Peptides.Molecules (Basel, Switzerland) · 2021Review
- Selective targeting of mutually exclusive DNA G-quadruplexes: HIV-1 LTR as paradigmatic model.Nucleic acids research · 2020Article
- Enhanced Hybridization Selectivity Using Structured GammaPNA Probes.Molecules (Basel, Switzerland) · 2020Article
- Fluorogenic PNA probes.Beilstein journal of organic chemistry · 2018Review
- DNA G-Wire Formation Using an Artificial Peptide is Controlled by Protease Activity.Molecules (Basel, Switzerland) · 2017Article
- Peptide nucleic acids: Advanced tools for biomedical applications.Journal of biotechnology · 2017Review
- Homologous PNA Hybridization to Noncanonical DNA G-Quadruplexes.Biochemistry · 2016Article
- Article
- Multivalent LKγ-PNA oligomers bind to a human telomere DNA G-rich sequence to form quadruplexes.Bioorganic & medicinal chemistry letters · 2015Article
- Small antisense oligonucleotides against G-quadruplexes: specific mRNA translational switches.Nucleic acids research · 2015Article
- Strand invasion of DNA quadruplexes by PNA: comparison of homologous and complementary hybridization.Chembiochem : a European journal of chemical biology · 2013Article
- Targeting DNA G-quadruplex structures with peptide nucleic acids.Current pharmaceutical design · 2012Review
- Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes.Chemical communications (Cambridge, England) · 2011Article
- Synthesis and characterization of conformationally preorganized, (R)-diethylene glycol-containing γ-peptide nucleic acids with superior hybridization properties and water solubility.The Journal of organic chemistry · 2011Article
- Targeting G-quadruplexes in gene promoters: a novel anticancer strategy?Nature reviews. Drug discovery · 2011Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Targeting guanine (G) quadruplex structures is an exciting new strategy with potential for controlling gene expression and designing anticancer agents. Guanine-rich peptide nucleic acid (PNA) oligomers bind to homologous DNA and RNA to form hetero-G-quadruplexes but can also bind to complementary cytosine-rich sequences to form heteroduplexes. In this study, we incorporated backbone modifications into G-rich PNAs to improve the selectivity for quadruplex versus duplex formation. Incorporation of abasic sites as well as chiral modifications to the backbone were found to be effective strategies for improving selectivity as shown by UV-melting and surface plasmon resonance measurements. The enhanced selectivity is due primarily to decreased affinity for complementary sequences, since binding to the homologous DNA to form PNA-DNA heteroquadruplexes retains high affinity. The improved selectivity of these PNAs is an important step toward using PNAs for regulating gene expression by G-quadruplex formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.