Evidence map›Paper›PMID 19946711›Full record

ReviewPediatric nephrology (Berlin, Germany)2010

Medium-size-vessel vasculitis.

Michael J Dillon, Despina Eleftheriou, Paul A Brogan

Open access · bronzeAbstract readReview
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 120 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Childhood Vasculitis.Indian journal of pediatrics · 2024
    Review
  6. Overview of childhood vasculitis.Journal of rheumatic diseases · 2024
    Review
  7. [Evidence-based guidelines for the diagnosis and treatment of Kawasaki disease in children in China (2023)].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Article
  8. Recent Advances in Pediatric Vasculitis.Rheumatic diseases clinics of North America · 2021
    Review
  9. Article
  10. Primary care approach to Kawasaki disease.Singapore medical journal · 2021
    Article
  11. Article
  12. Testicular ischemia in deficiency of adenosine deaminase 2 (DADA2).Pediatric rheumatology online journal · 2019
    Article
  13. Review
  14. Review
  15. Vasculitis update: pathogenesis and biomarkers.Pediatric nephrology (Berlin, Germany) · 2018
    Review
  16. Article
  17. Article
  18. Kawasaki disease: a matter of innate immunity.Clinical and experimental immunology · 2016
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael J DillonNephrourology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK. m.dillon@ich.ucl.ac.uk
Despina Eleftheriou
Paul A Brogan
University College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Medium-size-artery vasculitides do occur in childhood and manifest, in the main, as polyarteritis nodosa (PAN), cutaneous PAN and Kawasaki disease. Of these, PAN is the most serious, with high morbidity and not inconsequential mortality rates. New classification criteria for PAN have been validated that will have value in epidemiological studies and clinical trials. Renal involvement is common and recent therapeutic advances may result in improved treatment options. Cutaneous PAN is a milder disease characterised by periodic exacerbations and often associated with streptococcal infection. There is controversy as to whether this is a separate entity or part of the systemic PAN spectrum. Kawasaki disease is an acute self-limiting systemic vasculitis, the second commonest vasculitis in childhood and the commonest cause of childhood-acquired heart disease. Renal manifestations occur and include tubulointerstitial nephritis and renal failure. An infectious trigger and a genetic predisposition seem likely. Intravenous immunoglobulin (IV-Ig) and aspirin are effective therapeutically, but in resistant cases, either steroid or infliximab have a role. Greater understanding of the pathogenetic mechanisms involved in these three types of vasculitis and better long-term follow-up data will lead to improved therapy and prediction of prognosis.

Indexed as

ChildChild, PreschoolDisease ProgressionFemaleHeart DiseasesHumansKidney DiseasesMaleMucocutaneous Lymph Node SyndromePolyarteritis NodosaTreatment Outcome

Identifiers

PMID19946711
PMCPMC2908435
OpenAlexW1980627635

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.