ArticlePlanta2010
Tomato yellow leaf curl virus infection of a resistant tomato line with a silenced sucrose transporter gene LeHT1 results in inhibition of growth, enhanced virus spread, and necrosis.
Article in Planta, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 43 citations in OpenAlex.
- The Roles of Plant MicroRNAs in Defence Against Pathogens.Molecular plant pathology · 2026Review
- The Application of Virus-Induced Gene Silencing in the Study of Rose Petal Abscission.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Sugar transporters: mediators of carbon flow between plants and microbes.Frontiers in plant science · 2025Review
- The role of sugar transporters in the battle for carbon between plants and pathogens.Plant biotechnology journal · 2024Review
- Molecular mapping of the broad bean wilt virus 2 resistance locus bwvr in Capsicum annuum using BSR-seq.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- A new NLR gene for resistance to Tomato spotted wilt virus in tomato (Solanum lycopersicum).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Sugar conundrum in plant-pathogen interactions: roles of invertase and sugar transporters depend on pathosystems.Journal of experimental botany · 2022Article
- Geminivirus Resistance: A Minireview.Frontiers in plant science · 2020Review
- Tomato Leaf Curl New Delhi Virus: An Emerging Virus Complex Threatening Vegetable and Fiber Crops.Viruses · 2017Review
- Article
- Tomato plant cell death induced by inhibition of HSP90 is alleviated by Tomato yellow leaf curl virus infection.Molecular plant pathology · 2016Article
- Mapping in the era of sequencing: high density genotyping and its application for mapping TYLCV resistance in Solanum pimpinellifolium.BMC genomics · 2014Article
- Article
- Water Balance, Hormone Homeostasis, and Sugar Signaling Are All Involved in Tomato Resistance to Tomato Yellow Leaf Curl Virus.Plant physiology · 2014Article
- Involvement of host regulatory pathways during geminivirus infection: a novel platform for generating durable resistance.Functional & integrative genomics · 2014Review
- Review
- The Tomato Yellow Leaf Curl Virus resistance genes Ty-1 and Ty-3 are allelic and code for DFDGD-class RNA-dependent RNA polymerases.PLoS genetics · 2013Article
- Article
- Recent advances in tomato functional genomics: utilization of VIGS.Protoplasma · 2012Review
- A developmentally regulated lipocalin-like gene is overexpressed in Tomato yellow leaf curl virus-resistant tomato plants upon virus inoculation, and its silencing abolishes resistance.Plant molecular biology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To identify genes involved in resistance of tomato to Tomato yellow leaf curl virus (TYLCV), cDNA libraries from lines resistant (R) and susceptible (S) to the virus were compared. The hexose transporter LeHT1 was found to be expressed preferentially in R tomato plants. The role of LeHT1 in the establishment of TYLCV resistance was studied in R plants where LeHT1 has been silenced using Tobacco rattle virus-induced gene silencing (TRV VIGS). Following TYLCV inoculation, LeHT1-silenced R plants showed inhibition of growth and enhanced virus accumulation and spread. In addition, a necrotic response was observed along the stem and petioles of infected LeHT1-silenced R plants, but not on infected not-silenced R plants. This response was specific of R plants since it was absent in infected LeHT1-silenced S plants. Necrosis had several characteristics of programmed cell death (PCD): DNA from necrotic tissues presented a PCD-characteristic ladder pattern, the amount of a JNK analogue increased, and production of reactive oxygen was identified by DAB staining. A similar necrotic reaction along stem and petioles was observed in LeHT1-silenced R plants infected with the DNA virus Bean dwarf mosaic virus and the RNA viruses Cucumber mosaic virus and Tobacco mosaic virus. These results constitute the first evidence for a necrotic response backing natural resistance to TYLCV in tomato, confirming that plant defense is organized in multiple layers. They demonstrate that the hexose transporter LeHT1 is essential for the expression of natural resistance against TYLCV and its expression correlates with inhibition of virus replication and movement.
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