ArticleHistochemistry and cell biology2010
Expression of P2X6 receptors in the enteric nervous system of the rat gastrointestinal tract.
Article in Histochemistry and cell biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- Purinergic signaling in the gut neuro-glial-immune axis: mechanisms of homeostasis, inflammation, and gastrointestinal dysfunction.Frontiers in gastroenterology (Lausanne, Switzerland) · 2026Review
- Generalised Hodgkin-Huxley model captures human P2X and AMPA receptor currents.The Journal of physiology · 2026Article
- Review
- Enteric nervous system and inflammatory bowel diseases: Correlated impacts and therapeutic approaches through the P2X7 receptor.World journal of gastroenterology · 2021Review
- Blockage of the P2X7 Receptor Attenuates Harmful Changes Produced by Ischemia and Reperfusion in the Myenteric Plexus.Digestive diseases and sciences · 2019Article
- Intracellular emetic signaling cascades by which the selective neurokinin type 1 receptor (NKNeurochemistry international · 2019Article
- Physiological Concentrations of Zinc Have Dual Effects on P2X Myenteric Receptors of Guinea Pig.Cellular and molecular neurobiology · 2018Article
- Expression of P2X1 receptors in somatostatin-containing cells in mouse gastrointestinal tract and pancreatic islets of both mouse and human.Purinergic signalling · 2018Article
- LRG1 promotes angiogenesis through upregulating the TGF‑β1 pathway in ischemic rat brain.Molecular medicine reports · 2016Article
- Co-localization of Pirt protein and P2X2 receptors in the mouse enteric nervous system.Purinergic signalling · 2016Article
- Purinergic regulation of the immune system.Nature reviews. Immunology · 2016Review
- Neuroimmunomodulation in the Gut: Focus on Inflammatory Bowel Disease.Mediators of inflammation · 2016Review
- The Effect of Ischemia and Reperfusion on Enteric Glial Cells and Contractile Activity in the Ileum.Digestive diseases and sciences · 2015Article
- Huaier aqueous extract induces apoptosis of human fibrosarcoma HT1080 cells through the mitochondrial pathway.Oncology letters · 2015Article
- Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation.American journal of human genetics · 2015Article
- Differential effects of experimental ulcerative colitis on P2X7 receptor expression in enteric neurons.Histochemistry and cell biology · 2015Article
- Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob/ob).World journal of gastroenterology · 2014Article
- Effects of ischemia and reperfusion on subpopulations of rat enteric neurons expressing the P2X7 receptor.Digestive diseases and sciences · 2013Article
- Electroacupuncture diminishes P2X2 and P2X3 purinergic receptor expression in dorsal root ganglia of rats with visceral hypersensitivity.Neural regeneration research · 2013Article
- Expression of the P2X₂ receptor in different classes of ileum myenteric neurons in the female obese ob/ob mouse.World journal of gastroenterology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Expression of P2X(4) and P2X(6) receptor subunits in the gastrointestinal tract of the rat was studied with double-labeling fluorescence immunohistochemistry. The results showed that P2X(6) receptors were expressed widely in the submucosal and myenteric plexuses. In the myenteric plexus, P2X(6) receptors were expressed mainly in large size neurons which resembled Dogiel type II neurons. These P2X(6) receptor-immunoreactive (ir) neurons also expressed calbindin 28K, calretinin and neuronal nuclei (NeuN), proteins that are markers of intrinsic sensory neurons. In the submucosal plexus, all the calbindin 28K, calretinin and NeuN-ir cells were immunoreactive for P2X(6) receptors. P2X(6) receptors do not form homomultimers, but rather heteromultimers with either P2X(2) or P2X(4) receptors. P2X(4) receptors were not expressed in neurons, but were expressed in macrophages of the rat gastrointestinal tract. These data indicate that P2X(6) receptors are mainly expressed on intrinsic sensory neurons and that ATP, via P2X(6) receptors probably in heteromeric combination with P2X(2) receptors, may be involved in regulating the physiological functions of these neurons.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.