ArticleThe Journal of experimental biology2009
The peptide hormone pQDLDHVFLRFamide (crustacean myosuppressin) modulates the Homarus americanus cardiac neuromuscular system at multiple sites.
Article in The Journal of experimental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Peptidergic Modulation of the Lobster Cardiac System Has Opposing Action on Neurons and Muscles.Integrative organismal biology (Oxford, England) · 2025Article
- Neuropeptidomics of the American LobsterJournal of proteome research · 2024Article
- The role of feedback and modulation in determining temperature resiliency in the lobster cardiac nervous system.Frontiers in neuroscience · 2023Article
- Structural variation between neuropeptide isoforms affects function in the lobster cardiac system.General and comparative endocrinology · 2022Article
- Isoforms of the neuropeptide myosuppressin differentially modulate the cardiac neuromuscular system of the American lobster,Journal of neurophysiology · 2022Article
- Neuropeptidomic Profiling and Localization in the Crustacean Cardiac Ganglion Using Mass Spectrometry Imaging with Multiple Platforms.Journal of the American Society for Mass Spectrometry · 2020Article
- Cloning of the first cDNA encoding a putative CCRFamide precursor: identification of the brain, eyestalk ganglia, and cardiac ganglion as sites of CCRFamide expression in the American lobster, Homarus americanus.Invertebrate neuroscience : IN · 2020Article
- Differential neuropeptide modulation of premotor and motor neurons in the lobster cardiac ganglion.Journal of neurophysiology · 2020Article
- Identification of putative neuropeptidergic signaling systems in the spiny lobster, Panulirus argus.Invertebrate neuroscience : IN · 2020Article
- SIFamide peptides modulate cardiac activity differently in two species of Cancer crab.General and comparative endocrinology · 2019Article
- RNAi mediated myosuppressin deficiency affects muscle development and survival in the salmon louse (Lepeophtheirus salmonis).Scientific reports · 2019Article
- AMGSEFLamide, a member of a broadly conserved peptide family, modulates multiple neural networks inThe Journal of experimental biology · 2019Article
- Three members of a peptide family are differentially distributed and elicit differential state-dependent responses in a pattern generator-effector system.Journal of neurophysiology · 2018Article
- Prediction of a neuropeptidome for the eyestalk ganglia of the lobster Homarus americanus using a tissue-specific de novo assembled transcriptome.General and comparative endocrinology · 2017Article
- Forces generated during stretch in the heart of the lobster Homarus americanus are anisotropic and are altered by neuromodulators.The Journal of experimental biology · 2016Article
- Distinct or shared actions of peptide family isoforms: I. Peptide-specific actions of pyrokinins in the lobster cardiac neuromuscular system.The Journal of experimental biology · 2015Article
- Related neuropeptides use different balances of unitary mechanisms to modulate the cardiac neuromuscular system in the American lobster, Homarus americanus.Journal of neurophysiology · 2015Article
- Neuropeptidergic Signaling in the American Lobster Homarus americanus: New Insights from High-Throughput Nucleotide Sequencing.PloS one · 2015Article
- The neuromuscular transform of the lobster cardiac system explains the opposing effects of a neuromodulator on muscle output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia.The Journal of experimental biology · 2013Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
pQDLDHVFLRFamide is a highly conserved crustacean neuropeptide with a structure that places it within the myosuppressin subfamily of the FMRFamide-like peptides. Despite its apparent ubiquitous conservation in decapod crustaceans, the paracrine and/or endocrine roles played by pQDLDHVFLRFamide remain largely unknown. We have examined the actions of this peptide on the cardiac neuromuscular system of the American lobster Homarus americanus using four preparations: the intact animal, the heart in vitro, the isolated cardiac ganglion (CG), and a stimulated heart muscle preparation. In the intact animal, injection of myosuppressin caused a decrease in heartbeat frequency. Perfusion of the in vitro heart with pQDLDHVFLRFamide elicited a decrease in the frequency and an increase in the amplitude of heart contractions. In the isolated CG, myosuppressin induced a hyperpolarization of the resting membrane potential of cardiac motor neurons and a decrease in the cycle frequency of their bursting. In the stimulated heart muscle preparation, pQDLDHVFLRFamide increased the amplitude of the induced contractions, suggesting that myosuppressin modulates not only the CG, but also peripheral sites. For at least the in vitro heart and the isolated CG, the effects of myosuppressin were dose-dependent (10(-9) to 10(-6) mol l(-1) tested), with threshold concentrations (10(-8)-10(-7) mol l(-1)) consistent with the peptide serving as a circulating hormone. Although cycle frequency, a parameter directly determined by the CG, consistently decreased when pQDLDHVFLRFamide was applied to all preparation types, the magnitudes of this decrease differed, suggesting the possibility that, because myosuppressin modulates the CG and the periphery, it also alters peripheral feedback to the CG.
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