ArticleTrends in genetics : TIG2010
Paramutation: the tip of an epigenetic iceberg?
Article in Trends in genetics : TIG, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Review
- A role for epigenetic inheritance in modern evolutionary theory? A comment in response to Dickins and Rahman.Proceedings. Biological sciences · 2013Article
- Specific tandem repeats are sufficient for paramutation-induced trans-generational silencing.PLoS genetics · 2013Article
- Epigenetic inheritance of disease and disease risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2013Review
- Article
- The maize b1 paramutation control region causes epigenetic silencing in Drosophila melanogaster.Molecular genetics and genomics : MGG · 2012Article
- Article
- Transgenic epigenetics: using transgenic organisms to examine epigenetic phenomena.Genetics research international · 2012Article
- Ancestral paternal genotype controls body weight and food intake for multiple generations.Human molecular genetics · 2010Article
- Paramutation in maize: RNA mediated trans-generational gene silencing.Current opinion in genetics & development · 2010Review
- Transgenic expression of CBBP, a CXC domain protein, establishes paramutation in maize.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Paramutation describes the transfer of an acquired epigenetic state to an unlinked homologous locus, resulting in a meiotically heritable alteration in gene expression. Early investigations of paramutation characterized a mode of change and inheritance distinct from mendelian genetics, catalyzing the concept of the epigenome. Numerous examples of paramutation and paramutation-like phenomena have now emerged, with evidence that implicates small RNAs in the transfer and maintenance of epigenetic states. In animals Piwi-interacting RNA (piRNA)-mediated retrotransposon suppression seems to drive a vast system of epigenetic inheritance with paramutation-like characteristics. The classic examples of paramutation might be merely informative aberrations of pervasive and broadly conserved mechanisms that use RNA to sense homology and target epigenetic modification. When viewed in this context, paramutation is only one aspect of a common and broadly distributed form of inheritance based on epigenetic states.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.