ArticleSeminars in pediatric neurology2009
The encephalopathy of prematurity: one pediatric neuropathologist's perspective.
Article in Seminars in pediatric neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Early immune responses to systemic inflammation in the postnatal mouse brain initiated by migrating macrophages and leptomeningeal fibroblasts.Journal of neuroinflammation · 2025Article
- Assessment of Alcohol Exposure From Alcohol-Based Disinfectants Among Premature Infants in Neonatal Incubators in Japan.JAMA network open · 2023Article
- Erythropoietin as a Neuroprotective Drug for Newborn Infants: Ten Years after the First Use.Antioxidants (Basel, Switzerland) · 2022Review
- Synaptic Injury in the Thalamus Accompanies White Matter Injury in Hypoxia/Ischemia-Mediated Brain Injury in Neonatal Rats.BioMed research international · 2019Article
- Neuroinflammation in preterm babies and autism spectrum disorders.Pediatric research · 2019Review
- Hippocampus, Amygdala, and Thalamus Volumes in Very Preterm Children at 8 Years: Neonatal Pain and Genetic Variation.Frontiers in behavioral neuroscience · 2019Article
- Neonatal erythropoietin mitigates impaired gait, social interaction and diffusion tensor imaging abnormalities in a rat model of prenatal brain injury.Experimental neurology · 2018Article
- Clinical neuroimaging in the preterm infant: Diagnosis and prognosis.NeuroImage. Clinical · 2017Review
- Reduced thalamic volume in preterm infants is associated with abnormal white matter metabolism independent of injury.Neuroradiology · 2015Article
- Developmental expression of N-methyl-D-aspartate (NMDA) receptor subunits in human white and gray matter: potential mechanism of increased vulnerability in the immature brain.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Regional vulnerability of longitudinal cortical association connectivity: Associated with structural network topology alterations in preterm children with cerebral palsy.NeuroImage. Clinical · 2015Article
- Unmyelinated axon loss with postnatal hypertonia after fetal hypoxia.Annals of neurology · 2014Article
- Radial coherence of diffusion tractography in the cerebral white matter of the human fetus: neuroanatomic insights.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Evidence for a gender-specific protective role of innate immune receptors in a model of perinatal brain injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The protective effect of glibenclamide in a model of hemorrhagic encephalopathy of prematurity.Brain sciences · 2013Article
- 12/15-lipoxygenase expression is increased in oligodendrocytes and microglia of periventricular leukomalacia.Developmental neuroscience · 2013Article
- The role of cytokines and inflammatory cells in perinatal brain injury.Neurology research international · 2012Article
- Modeling the encephalopathy of prematurity in animals: the important role of translational research.Neurology research international · 2012Article
- Regional differences in susceptibility to hypoxic-ischemic injury in the preterm brain: exploring the spectrum from white matter loss to selective grey matter injury in a rat model.Neurology research international · 2012Article
- Tandem insults of prenatal ischemia plus postnatal raised intrathoracic pressure in a novel rat model of encephalopathy of prematurity.Journal of neurosurgery. Pediatrics · 2011Article
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Abstract
A major challenge in understanding brain injury in the premature brain is the establishment of the precise human neuropathology at the cellular and molecular levels, as such knowledge is the foundation upon which the elucidation of the cause(s), scientific experimentation, and therapies in the field is by necessity based. In this essay, I provide my perspective as a pediatric neuropathologist upon pathologic studies in the developing human brain itself, including a review of past, present, and future aspects. My focus is upon the path that has brought us to the current recognition that preterm brain injury is a complex of white and gray matter damage that results in the modification of key developmental pathways during a critical period, which in turn defines the adverse clinical outcomes as important as the primary insult itself. The evolution of this recognition, as well as the introduction of the term "encephalopathy of prematurity" for the complex of gray and white matter damage because of acquired and developmental mechanisms, is discussed. Our enhanced understanding of the fundamental neuropathology of the human preterm brain should bring us closer to more effective therapy as the need to prevent and treat injury to developing oligodendrocytes and neurons in combination is appreciated.
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