ArticleNeurotoxicology and teratology
Agmatine reduces ultrasonic vocalization deficits in female rat pups exposed neonatally to ethanol.
Article in Neurotoxicology and teratology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 27 citations in OpenAlex.
- Agmatine reduces alcohol drinking and produces antinociceptive effects in rodent models of alcohol use disorder.Alcohol (Fayetteville, N.Y.) · 2023Article
- Effects of Ethanol Exposure during Lactation on Ultrasonic Vocalizations of Rat Pups upon Their Isolation: Increase in Pup Distress Calls.Brain sciences · 2021Article
- Biological and Acoustic Sex Differences in Rat Ultrasonic Vocalization.Brain sciences · 2021Review
- The Effects of Perinatal Oxycodone Exposure on Behavioral Outcome in a Rodent Model.Frontiers in pediatrics · 2017Article
- Prenatal Ethanol Exposure and Whisker Clipping Disrupt Ultrasonic Vocalizations and Play Behavior in Adolescent Rats.Brain sciences · 2016Article
- Docosahexaenoic acid partially ameliorates deficits in social behavior and ultrasonic vocalizations caused by prenatal ethanol exposure.Behavioural brain research · 2015Article
- Polyamine modulation of NMDARs as a mechanism to reduce effects of alcohol dependence.Recent patents on CNS drug discovery · 2012Review
- Effects of chronic social stress during lactation on maternal behavior and growth in rats.Stress (Amsterdam, Netherlands) · 2011Article
- Social behavior of offspring following prenatal cocaine exposure in rodents: a comparison with prenatal alcohol.Frontiers in psychiatry · 2011Article
- Evaluation of Pax6 mutant rat as a model for autism.PloS one · 2010Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Rat pups, in isolation, produce ultrasonic vocalizations (USVs). These USVs have been used as a diagnostic tool for developmental toxicity. We have shown that neonatal ethanol (ETOH) exposure produces deficits in this behavior. The current study was designed to examine whether agmatine (AG), which binds to imidazoline receptors and modulates n-methyl-d-aspartate receptors (NMDAR), could reduce these deficits. In addition, this study examined critical periods for ETOH's effects on USVs by administering ETOH during either the 1st or 2nd postnatal week. Neonatal rats received intragastric intubations of either ETOH (6g/kg/day), ETOH and AG (6g/kg/day and 20mg/kg/day), AG (20mg/kg/day), or maltose on postnatal days (PND) 1-7 or 8-14. A non-intubated control was also included. Subjects were tested on PND 15. Neonatal ETOH exposure significantly increased the latency to vocalize for females and reduced the rate of USVs in both males and females exposed to ETOH on PND 1-7. Agmatine reduced these deficits, in female but not male pups. Subjects exposed to ETOH on PND 8-14 showed no evidence of abnormal USVs. These findings suggest that there may be gender differences in response to AG following neonatal ETOH exposure and also provide further support that the first neonatal week is a particularly sensitive time for the developmentally toxic effects of ETOH in rodents.
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