ReviewCell metabolism2009
Hyperinsulinism and diabetes: genetic dissection of beta cell metabolism-excitation coupling in mice.
Review in Cell metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 42 citations in OpenAlex.
- Causal network perturbation analysis identifies known and novel type-2 diabetes driver genes.bioRxiv : the preprint server for biology · 2024Article
- Genome-edited zebrafish model ofIslets · 2022Article
- Article
- ATP-Sensitive Potassium Channels in Hyperinsulinism and Type 2 Diabetes: Inconvenient Paradox or New Paradigm?Diabetes · 2022Review
- Computational Identification of Novel Kir6 Channel Inhibitors.Frontiers in pharmacology · 2019Article
- The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity.Cell death & disease · 2018Article
- Sulfonylurea challenge test in subjects diagnosed with type 1 diabetes mellitus.Pediatric diabetes · 2017Article
- Functional identification of islet cell types by electrophysiological fingerprinting.Journal of the Royal Society, Interface · 2017Article
- Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells.Royal Society open science · 2017Article
- All mixed up: defining roles for β-cell subtypes in mature islets.Genes & development · 2017Review
- Decreases in Gap Junction Coupling Recovers Ca2+ and Insulin Secretion in Neonatal Diabetes Mellitus, Dependent on Beta Cell Heterogeneity and Noise.PLoS computational biology · 2016Article
- Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection.Cardiac electrophysiology clinics · 2016Review
- A Novel Diphenylthiosemicarbazide Is a Potential Insulin Secretagogue for Anti-Diabetic Agen.PloS one · 2016Article
- ABCC9/SUR2 in the brain: Implications for hippocampal sclerosis of aging and a potential therapeutic target.Ageing research reviews · 2015Review
- Applying the logic of genetic interaction to discover small molecules that functionally interact with human disease alleles.Methods in molecular biology (Clifton, N.J.) · 2015Article
- Modeling K,ATP--dependent excitability in pancreatic islets.Biophysical journal · 2014Article
- Pancreatic β-cell-specific ablation of TASK-1 channels augments glucose-stimulated calcium entry and insulin secretion, improving glucose tolerance.Endocrinology · 2014Article
- Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.Cell metabolism · 2013Article
- A mouse model of human hyperinsulinism produced by the E1506K mutation in the sulphonylurea receptor SUR1.Diabetes · 2013Article
- Heterogeneity and function of K(ATP) channels in canine hearts.Heart rhythm · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The role of metabolism-excitation coupling in insulin secretion has long been apparent, but in recent years, in parallel with studies of human hyperinsulinism and diabetes, genetic manipulation of proteins involved in glucose transport, metabolism, and excitability in mice has brought the central importance of this pathway into sharp relief. We focus on these animal studies and how they provide important insights into not only metabolic and electrical regulation of insulin secretion, but also downstream consequences of alterations in this pathway and the etiology and treatment of insulin-secretion diseases in humans.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.