ArticleNeuron2009
DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina.
Article in Neuron, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 1 of them a synthesis that pooled it.
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Who cites it
158 citing papers in PubMed, 1 synthesis or guideline pooled it, 230 citations in OpenAlex.
- Genome-wide association study of posttraumatic stress disorder in a cohort of Iraq-Afghanistan era veterans.Journal of affective disorders · 2015Pooled it
- Molecular insights into electroreceptor ribbon synapses from differential gene expression in sturgeon lateral line organs.Journal of anatomy · 2026Article
- Reduced Neuronal Self-Avoidance in Mouse Starburst Amacrine Cells With Only One Pcdhg Isoform.Developmental neurobiology · 2026Article
- Future Directions for Studying the Potential of Mammalian Dscam in Autism Spectrum Disorder and Alzheimer's Disease: Insights from Dose Sensitivity.Molecular neurobiology · 2025Review
- Neurons maintain sequential order during radial migration by DSCAM-facilitated antagonism of N-Cadherin.bioRxiv : the preprint server for biology · 2025Article
- Reduced neuronal self-avoidance in mouse starburst amacrine cells with only onebioRxiv : the preprint server for biology · 2025Article
- Dscamb regulates cone mosaic formation in zebrafish via filopodium-mediated homotypic recognition.Nature communications · 2025Article
- Exploring perspectives of Dscam for cognitive deficits: a review of multifunction for regulating neural wiring in homeostasis.Frontiers in molecular neuroscience · 2025Review
- Pten regulates endocytic trafficking of cell adhesion and Wnt signaling molecules to pattern the retina.Cell reports · 2024Article
- The role of Down syndrome cell adhesion molecule in Down syndrome.Medical review (2021) · 2024Review
- Retinal neurons establish mosaic patterning by excluding homotypic somata from their dendritic territory.bioRxiv : the preprint server for biology · 2023Article
- Overexpression of EphB6 and EphrinB2 controls soma spacing of cortical neurons in a mutual inhibitory way.Cell death & disease · 2023Article
- MicroRNAs in the Mouse Developing Retina.International journal of molecular sciences · 2023Review
- Structure and evolution of neuronal wiring receptors and ligands.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Review
- The rod synapse in aging wildtype and Dscaml1 mutant mice.PloS one · 2023Article
- Student remote and distance research in neuroanatomy: Mapping Dscaml1 expression with a LacZ gene trap in mouse brain.Anatomia, histologia, embryologia · 2023Article
- Deficiency in the cell-adhesion moleculeFrontiers in cell and developmental biology · 2023Article
- Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors.Current biology : CB · 2022Article
- Channel-independent function of UNC-9/Innexin in spatial arrangement of GABAergic synapses ineLife · 2022Article
- Dual Leucine Zipper Kinase Regulates Dscam Expression through a Noncanonical Function of the Cytoplasmic Poly(A)-Binding Protein.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
98 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
DSCAM and DSCAM-LIKE1 (DSCAML1) serve diverse neurodevelopmental functions, including axon guidance, synaptic adhesion, and self-avoidance, depending on the species, cell type, and gene family member studied. We examined the function of DSCAM and DSCAML1 in the developing mouse retina. In addition to a subset of amacrine cells, Dscam was expressed in most retinal ganglion cells (RGCs). RGCs had fasciculated dendrites and clumped cell bodies in Dscam(-/-) mice, suggesting a role in self-avoidance. Dscaml1 was expressed in the rod circuit, and mice lacking Dscaml1 had fasciculated rod bipolar cell dendrites and clumped AII amacrine cell bodies, also indicating a role in self-avoidance. Neurons in Dscam or Dscaml1 mutant retinas stratified their processes appropriately in synaptic laminae in the inner plexiform layer, and functional synapses formed in the rod circuit in mice lacking Dscaml1. Therefore, DSCAM and DSCAML1 function similarly in self-avoidance, and are not essential for synaptic specificity in the mouse retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.