ReviewClinics in perinatology2009
Neonatal seizures: an update on mechanisms and management.
Review in Clinics in perinatology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06559410 (A Descriptive Study on Convulsions in Neonates With Congenital Heart Diseases at Assiut University Children Hospital), which is not on this map. Cited by 55 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Descriptive Study on Convulsions in Neonates With Congenital Heart Diseases at Assiut University Children Hospital
Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anti-seizure medications for neonates with seizures.The Cochrane database of systematic reviews · 2023Pooled it
- Methods of induction of labour: a network meta-analysis.The Cochrane database of systematic reviews · 2026Article
- Case Report: Early non-convulsive status epilepticus in a preterm infant with recurrent refractoryFrontiers in pediatrics · 2026Article
- Treatment considerations for the management of neonatal onset seizures.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Efficacy of phenobarbital is maintained after exposure to mild-to-moderate seizures in neonates.Epilepsia open · 2025Article
- Seizures May Worsen Outcomes of Neonatal Hypoxic-Ischemic Encephalopathy: A Longitudinal Serum Biomarkers Study.Pediatric neurology · 2025Article
- Pharmacokinetics and Pharmacodynamics of Levetiracetam in Neonatal Seizures: What We Still Need to Know.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2025Article
- Cannabidiol potentiates phenobarbital effects in the control of pentylenetetrazole (PTZ)-induced epileptic seizures in neonate rats.Frontiers in pediatrics · 2025Article
- Article
- Variable Association of Physiologic Changes With Electrographic Seizure-Like Events in Infants Born Preterm.The Journal of pediatrics · 2023Article
- Preclinical efficacy of cannabidiol for the treatment of early-life seizures.Pharmacological reports : PR · 2022Article
- SARS-CoV-2 Infection and Possible Neonatal Neurological Outcomes: A Literature Review.Viruses · 2022Review
- Lissencephaly causing refractory neonatal seizures in a term neonate.BMJ case reports · 2022Article
- Neonatal Seizure Management: Is the Timing of Treatment Critical?The Journal of pediatrics · 2022Article
- Quercetin Administration Following Hypoxia-Induced Neonatal Brain Damage Attenuates Later-Life Seizure Susceptibility and Anxiety-Related Behavior: Modulating Inflammatory Response.Frontiers in pediatrics · 2022Article
- Treating Seizures after Hypoxic-Ischemic Encephalopathy-Current Controversies and Future Directions.International journal of molecular sciences · 2021Review
- A Decision-Tree Approach to Assist in Forecasting the Outcomes of the Neonatal Brain Injury.International journal of environmental research and public health · 2021Article
- Neonatal Seizures and Purinergic Signalling.International journal of molecular sciences · 2020Review
- Investigating and managing neonatal seizures in the UK: an explanatory sequential mixed methods approach.BMC pediatrics · 2020Article
- Cannabinoids: A New Perspective on Epileptogenesis and Seizure Treatment in Early Life in Basic and Clinical Studies.Frontiers in behavioral neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The lifespan risk of seizures is highest in the neonatal period. Current therapies have limited efficacy. Although the treatment of neonatal seizures has not changed significantly in the last several decades, there has been substantial progress in understanding developmental mechanisms that influence seizure generation and responsiveness to anticonvulsants. This article provides an overview of current approaches to the diagnosis and treatment of neonatal seizures, and some of the recent insights about the pathophysiology of neonatal seizures that may provide the foundation for better treatment are identified.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.