ArticleBMC genomics2009
Development and bin mapping of a Rosaceae Conserved Ortholog Set (COS) of markers.
Article in BMC genomics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
- Inferring complex evolutionary history of the closely related East Asian wild roses in Rosa sect. Synstylae (Rosaceae) based on genomic evidence from conserved orthologues.Annals of botany · 2025Article
- Identification and assessment of variable single-copy orthologous (SCO) nuclear loci for low-level phylogenomics: a case study in the genus Rosa (Rosaceae).BMC evolutionary biology · 2019Article
- Article
- The Peach v2.0 release: high-resolution linkage mapping and deep resequencing improve chromosome-scale assembly and contiguity.BMC genomics · 2017Article
- Mapping X-Disease Phytoplasma Resistance inFrontiers in plant science · 2017Article
- Population genetic analysis of a global collection of Fragaria vesca using microsatellite markers.PloS one · 2017Article
- Narrowing down the single homoeologous FaPFRU locus controlling flowering in cultivated octoploid strawberry using a selective mapping strategy.Plant biotechnology journal · 2016Article
- Genomics of pear and other Rosaceae fruit trees.Breeding science · 2016Review
- Potato genetics, genomics, and applications.Breeding science · 2015Review
- Transcriptome sequencing and marker development for four underutilized legumes.Applications in plant sciences · 2015Article
- Article
- Comparative analysis of the radish genome based on a conserved ortholog set (COS) of Brassica.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2014Article
- Genomics and bioinformatics resources for translational science in Rosaceae.Plant biotechnology reports · 2014Review
- The Genome Database for Rosaceae (GDR): year 10 update.Nucleic acids research · 2014Article
- Molecular genetics and genomics of the Rosoideae: state of the art and future perspectives.Horticulture research · 2014Review
- QTL involved in the modification of cyanidin compounds in black and red raspberry fruit.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- The first genetic map of the American cranberry: exploration of synteny conservation and quantitative trait loci.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- Construction of an integrated high density simple sequence repeat linkage map in cultivated strawberry (Fragaria × ananassa) and its applicability.DNA research : an international journal for rapid publication of reports on genes and genomes · 2013Article
- Cell number regulator genes inMolecular breeding : new strategies in plant improvement · 2013Article
- Genome-wide characterization and linkage mapping of simple sequence repeats in mei (Prunus mume Sieb. et Zucc.).PloS one · 2013Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDetailed comparative genome analyses within the economically important Rosaceae family have not been conducted. This is largely due to the lack of conserved gene-based molecular markers that are transferable among the important crop genera within the family [e.g. Malus (apple), Fragaria (strawberry), and Prunus (peach, cherry, apricot and almond)]. The lack of molecular markers and comparative whole genome sequence analysis for this family severely hampers crop improvement efforts as well as QTL confirmation and validation studies.
resultsWe identified a set of 3,818 rosaceaous unigenes comprised of two or more ESTs that correspond to single copy Arabidopsis genes. From this Rosaceae Conserved Orthologous Set (RosCOS), 1039 were selected from which 857 were used for the development of intron-flanking primers and allele amplification. This led to successful amplification and subsequent mapping of 613 RosCOS onto the Prunus TxE reference map resulting in a genome-wide coverage of 0.67 to 1.06 gene-based markers per cM per linkage group. Furthermore, the RosCOS primers showed amplification success rates from 23 to 100% across the family indicating that a substantial part of the RosCOS primers can be directly employed in other less studied rosaceaous crops. Comparisons of the genetic map positions of the RosCOS with the physical locations of the orthologs in the Populus trichocarpa genome identified regions of colinearity between the genomes of Prunus-Rosaceae and Populus-Salicaceae.
conclusionConserved orthologous genes are extremely useful for the analysis of genome evolution among closely and distantly related species. The results presented in this study demonstrate the considerable potential of the mapped Prunus RosCOS for genome-wide marker employment and comparative whole genome studies within the Rosaceae family. Moreover, these markers will also function as useful anchor points for the genome sequencing efforts currently ongoing in this family as well as for comparative QTL analyses.
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