ArticleMolecular brain2009
Critical involvement of Rho GTPase activity in the efficient transplantation of neural stem cells into the injured spinal cord.
Article in Molecular brain, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Din Oversees Mesenchymal Stem Cell Homeostasis in Mouse Incisors.Research square · 2025Article
- Lineage tracing reveals transient phenotypic adaptation of tubular cells during acute kidney injury.iScience · 2024Article
- Constructing and Validating a Network of Potential Olfactory Sheathing Cell Transplants Regulating Spinal Cord Injury Progression.Molecular neurobiology · 2023Article
- Crosstalk between the Rho and Rab family of small GTPases in neurodegenerative disorders.Frontiers in cellular neuroscience · 2023Review
- RhoA-LIMK Signaling Axis Reveals Rostral-Caudal Plane and Spatial Dysregulation in the Brain of Alzheimer's Disease Mouse Models.Journal of Alzheimer's disease : JAD · 2023Article
- Taurine supplementation improves hippocampal metabolism in immature rats with intrauterine growth restriction (IUGR) through protecting neurons and reducing gliosis.Metabolic brain disease · 2022Article
- Role of Rho GTPases in stem cell regulation.Biochemical Society transactions · 2021Review
- Bioinformatics analysis of the wheel treadmill test on motor function recovery after spinal cord injury.Ibrain · 2021Article
- Identification of crucial genes associated with rat traumatic spinal cord injury.Molecular medicine reports · 2017Article
- [Effect of antepartum taurine supplementation in regulating the activity of Rho family factors and promoting the proliferation of neural stem cells in neonatal rats with fetal growth restriction].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Article
- Rho protein GTPases and their interactions with NFκB: crossroads of inflammation and matrix biology.Bioscience reports · 2014Review
- Rho family GTPases: key players in neuronal development, neuronal survival, and neurodegeneration.Frontiers in cellular neuroscience · 2014Review
- Cell Therapy From Bench to Bedside Translation in CNS Neurorestoratology Era.Cell medicine · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTransplantation of neural stem/progenitor cells is a promising approach toward functional restoration of the damaged neural tissue, but the injured spinal cord has been shown to be an adverse environment for the survival, migration, and differentiation of the donor cells. To improve the efficiency of cell replacement therapy, cell autonomous factors in the donor cells should be optimized. In light of recent findings that Rho family GTPases regulate stem cell functions, genetic manipulation of Rho GTPases can potentially control phenotypes of transplanted cells. Therefore we expressed mutant forms of Rho GTPases, Rac, Rho, and Cdc42, in the neural stem/progenitor cells and examined their survival and migration after transplantation.
resultsManipulation of the individual Rho GTPases showed differential effects on survival, with little variation in their migratory route and predominant differentiation into the oligodendroglial lineage. Combined suppression of both Rac and Rho activity had a prominent effect on promoting survival, consistent with its highly protective effect on drug-induced apoptosis in culture.
conclusionManipulation of Rac and Rho activities fully rescued suppression of cell survival induced by the spinal cord injury. Our results indicate that precise regulation of cell autonomous factors within the donor cells can ameliorate the detrimental environment created by the injury.
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