ArticleMolecular microbiology2010
Pseudomonas aeruginosa OspR is an oxidative stress sensing regulator that affects pigment production, antibiotic resistance and dissemination during infection.
Article in Molecular microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 77 citations in OpenAlex.
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- The transcriptional regulators of virulence forGenes & diseases · 2023Review
- An untargeted exometabolomics approach to characterize dissolved organic matter in groundwater of the Samail Ophiolite.Frontiers in microbiology · 2023Article
- Natural killer cells kill extracellular Pseudomonas aeruginosa using contact-dependent release of granzymes B and H.PLoS pathogens · 2022Article
- Green synthesis of silver nanoparticles fromFrontiers in microbiology · 2022Article
- BosR: A novel biofilm-specific regulator inFrontiers in microbiology · 2022Article
- Recent Advances in the Mechanisms and Regulation of QS in Dairy Spoilage byFoods (Basel, Switzerland) · 2021Review
- The MarR family regulator OsbR controls oxidative stress response, anaerobic nitrate respiration, and biofilm formation in Chromobacterium violaceum.BMC microbiology · 2021Article
- Oxidative Stress Response inPathogens (Basel, Switzerland) · 2021Review
- Article
- Genome-Wide Mapping Reveals Complex Regulatory Activities of BfmR inMicroorganisms · 2021Article
- Oxidative Stress Influences Pseudomonas aeruginosa Susceptibility to Antibiotics and Reduces Its Pathogenesis in Host.Current microbiology · 2020Article
- Assessing the Risk of Transfer of Microorganisms at the International Space Station Due to Cargo Delivery by Commercial Resupply Vehicles.Frontiers in microbiology · 2020Article
- Antibiotic ResistantFoods (Basel, Switzerland) · 2019Review
- Regulation of the Synthesis and Secretion of the Iron Chelator Cyclodipeptide Pulcherriminic Acid in Bacillus licheniformis.Applied and environmental microbiology · 2018Article
- Pseudomonas aeruginosamSphere · 2018Article
- The XRE Family Transcriptional Regulator SrtR inFrontiers in cellular and infection microbiology · 2018Article
- Coumarin Reduces Virulence and Biofilm Formation inFrontiers in microbiology · 2018Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Oxidative stress is one of the main challenges bacteria must cope with during infection. Here, we identify a new oxidative stress sensing and response ospR (oxidative stress response and pigment production Regulator) gene in Pseudomonas aeruginosa. Deletion of ospR leads to a significant induction in H(2)O(2) resistance. This effect is mediated by de-repression of PA2826, which lies immediately upstream of ospR and encodes a glutathione peroxidase. Constitutive expression of ospR alters pigment production and beta-lactam resistance in P. aeruginosa via a PA2826-independent manner. We further discovered that OspR regulates additional genes involved in quorum sensing and tyrosine metabolism. These regulatory effects are redox-mediated as addition of H(2)O(2) or cumene hydroperoxide leads to the dissociation of OspR from promoter DNA. A conserved Cys residue, Cys-24, plays the major role of oxidative stress sensing in OspR. The serine substitution mutant of Cys-24 is less susceptible to oxidation in vitro and exhibits altered pigmentation and beta-lactam resistance. Lastly, we show that an ospR null mutant strain displays a greater capacity for dissemination than wild-type MPAO1 strain in a murine model of acute pneumonia. Thus, OspR is a global regulator that senses oxidative stress and regulates multiple pathways to enhance the survival of P. aeruginosa inside host.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.