ReviewSurgical infections2009
Role of the host defense system and intestinal microbial flora in the pathogenesis of necrotizing enterocolitis.
Review in Surgical infections, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Are Immune Modulating Single Nucleotide Polymorphisms Associated with Necrotizing Enterocolitis?Scientific reports · 2015Trial
- A Review of Probiotic Interventions for Necrotizing Enterocolitis and Sepsis in Preterm Infants.International journal of molecular sciences · 2026Review
- Article
- Analyzing the Complicated Connection Between Intestinal Microbiota and Cardiovascular Diseases.Cureus · 2022Review
- The effects of IGF-1 and erythropoietin on apoptosis and telomerase activity in necrotizing enterocolitis model.Pediatric research · 2021Article
- Effects of Antibiotic Treatment and Probiotics on the Gut Microbiome of 40 Infants Delivered Before Term by Cesarean Section Analysed by Using 16S rRNA Quantitative Polymerase Chain Reaction Sequencing.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Inhibition of HMGB1 improves necrotizing enterocolitis by inhibiting NLRP3 via TLR4 and NF-κB signaling pathways.Journal of cellular physiology · 2019Article
- Intestinal Microbiota in Early Life and Its Implications on Childhood Health.Genomics, proteomics & bioinformatics · 2019Review
- Repertoire of Abs primed by bacteria in gnotobiotic mice.Innate immunity · 2018Article
- Oral citrulline supplementation protects female mice from the development of non-alcoholic fatty liver disease (NAFLD).European journal of nutrition · 2017Article
- Animal models for studying epithelial barriers in neonatal necrotizing enterocolitis, inflammatory bowel disease and colorectal cancer.Tissue barriers · 2017Review
- Can probiotics modulate human disease by impacting intestinal barrier function?The British journal of nutrition · 2017Review
- Colonization with Escherichia coli EC 25 protects neonatal rats from necrotizing enterocolitis.PloS one · 2017Article
- Addressing the Antibiotic Resistance Problem with Probiotics: Reducing the Risk of Its Double-Edged Sword Effect.Frontiers in microbiology · 2016Review
- The ErbB4 ligand neuregulin-4 protects against experimental necrotizing enterocolitis.The American journal of pathology · 2014Article
- Late onset of necrotizing enterocolitis in the full-term infant is associated with increased mortality: results from a two-center analysis.Journal of pediatric surgery · 2014Article
- Cronobacter: an emerging opportunistic pathogen associated with neonatal meningitis, sepsis and necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2013Review
- Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns.Fetal and pediatric pathology · 2013Article
- The role of the intestinal microbiota in the pathogenesis of necrotizing enterocolitis.Seminars in pediatric surgery · 2013Review
- Paneth cells and necrotizing enterocolitis: a novel hypothesis for disease pathogenesis.Neonatology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNecrotizing enterocolitis (NEC) is a devastating disease that affects primarily the intestine of premature infants. Despite recent advances in neonatology, NEC remains a major cause of morbidity and mortality in neonates. Neonatal mucosal defenses and adherence of bacterial pathogens may play an important role in the pathogenesis of NEC.
methodsReview and synthesis of pertinent literature.
resultsPutative factors that have been implicated in the pathogenesis of NEC include abnormal patterns of gut colonization by bacteria, immaturity of the host immune system and mucosal defense mechanisms, intestinal ischemia, formula feeding, and loss of intestinal epithelial barrier integrity.
conclusionHost defenses and intestinal microbial ecology are believed to play important roles in the pathogenesis of NEC. Commensal bacteria and probiotic therapy may be of therapeutic utility in the maintenance of the gut epithelial barrier.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.