ArticleNeurochemical research2010
mRNA expression of proteins involved in iron homeostasis in brain regions is altered by age and by iron overloading in the neonatal period.
Article in Neurochemical research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Impact of high iron intake on cognition and neurodegeneration in humans and in animal models: a systematic review.Nutrition reviews · 2017Pooled it
- Chalcone-based Turn-Off Chemosensor for Selective and Susceptible Detection of FeJournal of fluorescence · 2025Article
- Iron Trace Elements Concentration in PMBiomedicines · 2024Article
- A Solvent-Mediated Excited-State Intermolecular Proton Transfer Fluorescent Probe for FeMolecules (Basel, Switzerland) · 2022Article
- Article
- Nitrogen-doped carbon dots for sensitive detection of ferric ions and monohydrogen phosphate by the naked eye and imaging in living cells.Nanoscale advances · 2021Article
- Article
- Self-Assembly Fluorescent Cationic Cellulose Nanocomplex via Electrostatic Interaction for the Detection of FeNanomaterials (Basel, Switzerland) · 2019Article
- Antiapoptotic effects of cannabidiol in an experimental model of cognitive decline induced by brain iron overload.Translational psychiatry · 2018Article
- Excess iron intake as a factor in growth, infections, and development of infants and young children.The American journal of clinical nutrition · 2017Review
- Expression of Iron Transporters and Pathological Hallmarks of Parkinson's and Alzheimer's Diseases in the Brain of Young, Adult, and Aged Rats.Molecular neurobiology · 2017Article
- RETRACTED: Pyrene-Phosphonate Conjugate: Aggregation-Induced Enhanced Emission, and Selective FeMolecules (Basel, Switzerland) · 2017Article
- Is early-life iron exposure critical in neurodegeneration?Nature reviews. Neurology · 2015Review
- Sleep patterns in male juvenile monkeys are influenced by gestational iron deprivation and monoamine oxidase A genotype.The British journal of nutrition · 2014Article
- Iron and mechanisms of neurotoxicity.International journal of Alzheimer's disease · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormally high levels of iron are observed in the brain of patients suffering from neurodegenerative disorders. The mechanisms involved in iron accumulation in neurodegenerative disorders remain poorly understood. In the present study we investigated the effects of aging and neonatal iron overload on the mRNA expression of proteins critically involved in controlling iron homeostasis. Wistar rat pups received a single daily dose of vehicle or iron (10 mg/kg of b.w. of Fe(2+)), at postnatal days 12-14. The expression of Transferrin Receptor (TfR), H-Ferritin, and IRP2 were analyzed by a semi-quantitative reverse transcriptase polymerase chain reaction assay in cortex, hippocampus and striatum of rats sacrificed at three different ages (15-day-old; 90-day-old and 2-year old rats). Results indicate that TfR, H-ferritin, and IRP2 mRNA expression was differentially affected by aging and by neonatal iron treatment in all three brain regions. These findings might have implications for the understanding of iron homeostasis misregulation associated with neurodegenerative disorders.
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