ReviewEuropean journal of applied physiology2010
Impact of inactivity and exercise on the vasculature in humans.
Review in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers, 12 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
115 citing papers in PubMed, 12 syntheses or guidelines pooled it, 301 citations in OpenAlex.
- Functional Electrical Stimulation Cycling for Balance Rehabilitation in Stroke Survivors: A Systematic Review and Meta-Analysis.Artificial organs · 2026Pooled it
- Pooled it
- Physical activity trajectories and accumulation over adulthood and their associations with all-cause and cause-specific mortality: a systematic review and meta-analysis.British journal of sports medicine · 2025Pooled it
- Impacts of Physical Inactivity Models on Endothelial Function: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2025Pooled it
- Associations Between Exercise Training, Physical Activity, Sedentary Behaviour and Mortality: An Umbrella Review of Meta-Analyses.Journal of cachexia, sarcopenia and muscle · 2025Pooled it
- Pooled it
- Effect of continuous aerobic exercise on endothelial function: A systematic review and meta-analysis of randomized controlled trials.Frontiers in physiology · 2023Pooled it
- Exercise and Circulating Microparticles in Healthy Subjects.Journal of cardiovascular translational research · 2021Pooled it
- The Efficacy of Stretching Exercises on Arterial Stiffness in Middle-Aged and Older Adults: A Meta-Analysis of Randomized and Non-Randomized Controlled Trials.International journal of environmental research and public health · 2020Pooled it
- Impact of sedentary behavior on large artery structure and function in children and adolescents: a systematic review.European journal of pediatrics · 2020Pooled it
- Meta-analysis of Exercise Training on Vascular Endothelial Function in Cancer Survivors.Integrative cancer therapies · 2018Pooled it
- The impact of age on vascular smooth muscle function in humans.Journal of hypertension · 2015Pooled it
- Targeted Nrf2 activation improves vascular endothelial function with aging and prevents vascular dysfunction following disuse in younger and older adults.Free radical biology & medicine · 2026Trial
- Differential impacts of jogging and rope skipping in college students in China based on physical test score: a randomized controlled trial baseline indicator comparison in the intervention.Frontiers in public health · 2025Trial
- Blood flow restriction in the presence or absence of muscle contractions does not preserve vasculature structure and function following 14-days of limb immobilization.European journal of applied physiology · 2021Trial
- Cocoa Flavanols Improve Vascular Responses to Acute Mental Stress in Young Healthy Adults.Nutrients · 2021Trial
- Effect of Tai Chi on Cardiac and Static Pulmonary Function in Older Community-Dwelling Adults at Risk of Ischemic Stroke: A Randomized Controlled Trial.Chinese journal of integrative medicine · 2019Trial
- Associations of Reducing Sedentary Time With Vascular Function and Insulin Sensitivity in Older Sedentary Adults.American journal of hypertension · 2016Trial
- Effect of Chinese herbal medicine on vascular functions during 60-day head-down bed rest.European journal of applied physiology · 2015Trial
- The effect of an advanced glycation end-product crosslink breaker and exercise training on vascular function in older individuals: a randomized factorial design trial.Experimental gerontology · 2013Trial
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of inactivity and exercise training on established and novel cardiovascular risk factors are relatively modest and do not account for the impact of inactivity and exercise on vascular risk. We examine evidence that inactivity and exercise have direct effects on both vasculature function and structure in humans. Physical deconditioning is associated with enhanced vasoconstrictor tone and has profound and rapid effects on arterial remodelling in both large and smaller arteries. Evidence for an effect of deconditioning on vasodilator function is less consistent. Studies of the impact of exercise training suggest that both functional and structural remodelling adaptations occur and that the magnitude and time-course of these changes depends upon training duration and intensity and the vessel beds involved. Inactivity and exercise have direct "vascular deconditioning and conditioning" effects which likely modify cardiovascular risk.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.