ReviewCurrent opinion in genetics & development2010
Intravital imaging of stromal cell dynamics in tumors.
Review in Current opinion in genetics & development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Intravital Microscopy Reveals Endothelial Transcytosis Contributing to Significant Tumor Accumulation of Albumin Nanoparticles.Pharmaceutics · 2023Article
- Article
- Article
- Crosshatch nanofiber networks of tunable interfiber spacing induce plasticity in cell migration and cytoskeletal response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Intravital microscopy in the study of the tumor microenvironment: from bench to human application.Oncotarget · 2018Review
- Assessing multiparametric drug response in tissue engineered tumor microenvironment models.Methods (San Diego, Calif.) · 2018Article
- Imaging of anticancer drug action in single cells.Nature reviews. Cancer · 2017Review
- Review
- Characterization of the Tumor Microenvironment and Tumor-Stroma Interaction by Non-invasive Preclinical Imaging.Frontiers in oncology · 2017Review
- Development of novel murine mammary imaging windows to examine wound healing effects on leukocyte trafficking in mammary tumors with intravital imaging.Intravital · 2016Article
- The Use of Second Harmonic Generation to Image the Extracellular Matrix During Tumor Progression.Intravital · 2014Article
- Real-time imaging of myeloid cells dynamics in ApcMin/+ intestinal tumors by spinning disk confocal microscopy.Journal of visualized experiments : JoVE · 2014Article
- Imaging hallmarks of cancer in living mice.Nature reviews. Cancer · 2014Review
- Tumor microenvironment revisited.EMBO reports · 2014Article
- Developments in preclinical cancer imaging: innovating the discovery of therapeutics.Nature reviews. Cancer · 2014Review
- Piperlongumine inhibits migration of glioblastoma cells via activation of ROS-dependent p38 and JNK signaling pathways.Oxidative medicine and cellular longevity · 2014Article
- Emerging role of TRP channels in cell migration: from tumor vascularization to metastasis.Frontiers in physiology · 2013Review
- Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer.Oncoimmunology · 2013Article
- Fibroblasts and the ground they walk on.Physiology (Bethesda, Md.) · 2013Review
- Live imaging of drug responses in the tumor microenvironment in mouse models of breast cancer.Journal of visualized experiments : JoVE · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Tumor stroma, consisting of the extracellular matrix and multiple cell types such as immune cells, fibroblasts and vascular cells, contributes to the malignancy of solid tumors by a variety of mechanisms. Intravital imaging by different microscopy techniques, especially by confocal and multi-photon microscopy, has proven to be a powerful method for analyzing the cell-cell and cell-matrix interactions in the dynamic tumor microenvironments. Intravital imaging has fostered the acquisition of data on parameters such as motility of different cell types in distinct tumor regions or manipulated with defined challenges, kinetics of tumor cell killing by T cells or macrophage-assisted tumor cell extravasation, functionality of the vasculature, protease activity and metabolic state. Achieving the direct observation of intact tumors offered by intravital imaging provides unique insights into tumor biology that will continue to deepen our understanding of the processes leading to malignancy and of the ways they can be targeted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.