ArticleBiomaterials2010
Injectable in situ cross-linking hydrogels for local antifungal therapy.
Article in Biomaterials, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 136 citations in OpenAlex.
- A Comprehensive Review on Engineering Release at the Molecular Level: Role of Functional Groups in Polysaccharide-Based Drug Delivery.Materials (Basel, Switzerland) · 2026Review
- Hybrid Nanoparticle-Hydrogel Systems for Drug Delivery Depots and Other Biomedical Applications.ACS nano · 2024Review
- Injectable hydrogel based on liposome self-assembly for controlled release of small hydrophilic molecules.Acta biomaterialia · 2024Article
- Controlled Sr(ii) ion release fromRSC advances · 2024Article
- Wound Dressing Double-Crosslinked Quick Self-Healing Hydrogel Based on Carboxymethyl Chitosan and Modified Nanocellulose.Polymers · 2023Article
- The impact of varying dextran oxidation levels on the inhibitory activity of a bacteriocin loaded injectable hydrogel.Drug delivery and translational research · 2023Article
- Microwave-Assisted Synthesis of Modified Glycidyl Methacrylate-Ethyl Methacrylate Oligomers, Their Physico-Chemical and Biological Characteristics.Molecules (Basel, Switzerland) · 2022Article
- Polymers as advanced antibacterial and antibiofilm agents for direct and combination therapies.Chemical science · 2022Review
- Sustained intrathecal delivery of amphotericin B using an injectable and biodegradable thermogel.Drug delivery · 2021Article
- Inhibitory Effect of pH-Responsive Nanogel Encapsulating Ginsenoside CK against Lung Cancer.Polymers · 2021Article
- Hydrogel-Based Active Substance Release Systems for Cosmetology and Dermatology Application: A Review.Pharmaceutics · 2020Review
- Hydrogels as Potential Nano-, Micro- and Macro-Scale Systems for Controlled Drug Delivery.Materials (Basel, Switzerland) · 2020Review
- In Situ Crosslinking Bionanocomposite Hydrogels with Potential for Wound Healing Applications.Journal of functional biomaterials · 2019Article
- Development of tannin-inspired antimicrobial bioadhesives.Acta biomaterialia · 2018Article
- Chemical Synthesis of Biomimetic Hydrogels for Tissue Engineering.Polymer international · 2017Article
- Advances in the Fabrication of Antimicrobial Hydrogels for Biomedical Applications.Materials (Basel, Switzerland) · 2017Review
- Click chemistry improved wet adhesion strength of mussel-inspired citrate-based antimicrobial bioadhesives.Biomaterials · 2017Article
- Silver nanoparticles-containing dual-function hydrogels based on a guar gum-sodium borohydride system.Scientific reports · 2016Article
- Flow and Thixotropic Parameters for Rheological Characterization of Hydrogels.Molecules (Basel, Switzerland) · 2016Article
- Synthesis and characterization of anti-bacterial and anti-fungal citrate-based mussel-inspired bioadhesives.Biomaterials · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Invasive fungal infections can be devastating, particularly in immunocompromised patients, and difficult to treat with systemic drugs. Furthermore, systemic administration of those medications can have severe side effects. We have developed an injectable local antifungal treatment for direct administration into existing or potential sites of fungal infection. Amphotericin B (AmB), a hydrophobic, potent, and broad-spectrum antifungal agent, was rendered water-soluble by conjugation to a dextran-aldehyde polymer. The dextran-aldehyde-AmB conjugate retained antifungal efficacy against Candida albicans. Mixing carboxymethylcellulose-hydrazide with dextran-aldehyde formed a gel that cross-linked in situ by formation of hydrazone bonds. The gel provided in vitro release of antifungal activity for 11 days, and contact with the gel killed Candida for three weeks. There was no apparent tissue toxicity in the murine peritoneum and the gel caused no adhesions. Gels produced by entrapment of a suspension of AmB in CMC-dextran without conjugation of drug to polymers did not release fungicidal activity, but did kill on contact. Injectable systems of these types, containing soluble or insoluble drug formulations, could be useful for treatment of local antifungal infections, with or without concurrent systemic therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.