ReviewBest practice & research. Clinical gastroenterology2009
Colon cancer and the elderly: from screening to treatment in management of GI disease in the elderly.
Review in Best practice & research. Clinical gastroenterology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Integrating multimodal prehabilitation into enhanced recovery after surgery programs (MPhERAS) for elderly patients: a systematic review and meta-analysis of randomized controlled trials and cohort studies.Techniques in coloproctology · 2025Pooled it
- Pooled it
- Safety and Efficacy of Low-Volume Preparation in the Elderly: Oral Sulfate Solution on the Day before and Split-Dose Regimens (SEE SAFE) Study.Gut and liver · 2019Trial
- Hypnosis can reduce pain in hospitalized older patients: a randomized controlled study.BMC geriatrics · 2016Trial
- Improving Colorectal Cancer Screening and Risk Assessment through Predictive Modeling on Medical Images and Records.The American journal of pathology · 2026Article
- Intussusception risk factors and outcomes in adult and elderly patients: analysis from the national inpatient sample.Langenbeck's archives of surgery · 2025Article
- Oncologic outcomes of surgically treated colorectal cancer in octogenarians: a comparative study using inverse probability of treatment weighting (IPTW).BMC gastroenterology · 2025Article
- Article
- Article
- Impact of laparoscopic surgery on short-term and long-term outcomes in elderly obese patients with colon cancer.Annals of gastroenterological surgery · 2023Article
- Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer.Cell metabolism · 2023Article
- The Role of SOX Transcription Factors in Ageing and Age-Related Diseases.International journal of molecular sciences · 2023Review
- Upregulation of p16INK4A in Peripheral White Blood Cells as a Novel Screening Marker for Colorectal Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Toxicities and outcomes of neoadjuvant treatment in elderly patients with locally advanced rectal cancer: a scoping review protocol.BMJ open · 2022Article
- Improved supervised prediction of aging-related genes via weighted dynamic network analysis.BMC bioinformatics · 2021Article
- Utilisation of Adjuvant Chemotherapy and 5-Year Survival Analysis of Prospectively Recorded Cohort Data for Older Adults Versus Younger Adults with Resected Primary Colon Cancer.Journal of gastrointestinal cancer · 2020Article
- Unrelated Death After Colorectal Cancer Screening: Implications for Improving Colonoscopy Referrals.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2019Article
- Berberine regulates the microRNA-21-ITGΒ4-PDCD4 axis and inhibits colon cancer viability.Oncology letters · 2018Article
- Octogenarian patients with colorectal cancer: Characterizing an emerging clinical entity.World journal of gastroenterology · 2017Article
- Complete response to capecitabine in a frail, elderly patient with metastatic colorectal cancer: A case report.Oncology letters · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Colorectal cancer is one of the commonest tumours in the Westernized world affecting mainly the elderly. This neoplasm in older individuals occurs more often in the right colon and grows more rapidly than in the young, often shows a mucinous histology and mismatch repair gene changes. Effective screening permits discovery of colorectal cancer at an early highly treatable stage and allows for detection and removal of premalignant colorectal adenomas. Screening methods that focus on cancer detection use fecal assays for the presence of blood or altered DNA, those for detection of adenomas (and early cancer) use endoscopic or computerised radiologic techniques. Broad use of screening methods has lowered colorectal cancer development by about 50%. In addition, prevention of the earliest stage of colon carcinogenesis has been shown to be effective in small prospective studies and epidemiologic surveys but have not been employed in the general population. Since 1996 the chemotherapeutic armamentarium for metastatic colorectal cancer has grown beyond 5-fluorouracil to include an oral 5-fluorouracil prodrug, capecitabine as well as irinotecan and oxaliplatin. Three targeted monoclonal antibodies (Moabs), bevacizumab (an anti-vascular endothelial growth factor Moab) and cetuximab/panitumumab, both anti-epidermal growth factor receptor inhibitors, have also earned regulatory approval. Most stage IV patients are treated with all of these drugs over 2 or 3 sequential lines of palliative chemotherapy and attain median survivals approaching 24 months. Lastly, adjuvant oxaliplatin plus 5-fluorouracil for high risk resected stage II and stage III colon cancer patient has led to substantial improvement in cure rates. With appropriate care of age associated comorbidities these treatment modalities are feasible and effective in the geriatric population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.