ReviewBest practice & research. Clinical endocrinology & metabolism2009
Interferon induced thyroiditis.
Review in Best practice & research. Clinical endocrinology & metabolism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 123 citations in OpenAlex.
- Exploring autoimmune endocrine diseases induced by monoclonal antibodies used as multiple sclerosis pharmacotherapy: a systematic review.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Comparison of treatment outcome between glucocorticoids and non-steroidal anti-inflammatory drugs in subacute thyroiditis patients-a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Thyroid function disorders and secondary cancer following haematopoietic stem cell transplantation in pediatrics: State of the art and practical recommendations for a risk-based follow-up.Frontiers in endocrinology · 2022Pooled it
- Autoimmunity and peginterferon therapy for polycythemia vera.HemaSphere · 2026Review
- Microbiome and thyroid diseases: future precision studies of the gut-thyroid axis to facilitate the adjuvant treatment.Iranian journal of microbiology · 2026Review
- Hepatitis C Virus Infection Induces Autoimmune Hypothyroidism with Potential Profound Metabolic Implications: A Cross-Sectional Study in a High-Prevalence Region.Metabolites · 2026Article
- Case Report: Anti-TNF-α therapy-associated destructive thyroiditis and unmasking of latent amyloid A amyloidosis in rheumatoid arthritis.Frontiers in immunology · 2026Article
- Are single nucleotide polymorphisms in the IL-2 gene biomarkers for Hashimoto's thyroiditis?Medicine and pharmacy reports · 2024Article
- Silent Thyroiditis Associated with Ropeginterferon α-2b in a Patient with Polycythemia Vera.Internal medicine (Tokyo, Japan) · 2024Article
- Co-Morbid Hypothyroidism and Liver Dysfunction: A Review.Clinical medicine insights. Endocrinology and diabetes · 2024Review
- Thyroid Autoimmunity and SARS-CoV-2 Infection.Journal of clinical medicine · 2023Review
- Impact of COVID-19 on thyroid gland functions with reference to Graves' disease: A systematic review.Journal of family medicine and primary care · 2023Review
- Analysis of clinical characteristics of thyroid disorders in patients with chronic hepatitis B treated with pegylated-interferon alpha.BMC endocrine disorders · 2023Article
- Direct-acting antivirals used in HCV-related liver disease do not affect thyroid function and autoimmunity.Journal of endocrinological investigation · 2023Article
- Permanent hypothyroidism following immune checkpoint inhibitors induced thyroiditis may be associated with improved survival: results of an exploratory study.Frontiers in endocrinology · 2023Observational
- Fatal Case of Possible Thyroid Crisis Induced by SARS-CoV-2 Infection: A Case Report.Journal of the ASEAN Federation of Endocrine Societies · 2022Article
- Subclinical hypothyroidism in children: updates for pediatricians.Annals of pediatric endocrinology & metabolism · 2021Article
- [Clinical practice guidelines for acute and chronic thyroiditis (excluding autoimmune thyroiditis)].Problemy endokrinologii · 2021Article
- Endocrinopathies in Aicardi Goutières syndrome-A descriptive case series.Clinical case reports · 2020Article
- Thyroid disturbances in children treated with combined pegylated interferon-alpha and ribavirin for chronic hepatitis C.Clinical and experimental pediatrics · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Interferon-alpha (IFNalpha) is used for the treatment of various disorders, most notable chronic hepatitis C virus (HCV) infection. One of the commonest side effects of IFNalpha therapy is thyroiditis, with up to 40% of HCV patients on IFNalpha developing clinical or subclinical disease. In some cases interferon induced thyroiditis (IIT) may result in severe symptomatology necessitating discontinuation of therapy. IIT can manifest as clinical autoimmune thyroiditis, presenting with symptoms of classical Hashimoto's thyroiditis or Graves' disease, or as non-autoimmune thyroiditis. Non-autoimmune thyroiditis can manifest as destructive thyroiditis, with early thyrotoxicosis and later hypothyroidism, or as non-autoimmune hypothyroidism. While the epidemiology and clinical presentation of IIT have been well characterized the mechanisms causing IIT are still poorly understood. It is likely that the hepatitis C virus (HCV) itself plays a role in the disease, as the association between HCV infection and thyroiditis is well established. It is believed that IFNalpha induces thyroiditis by both immune stimulatory effects and by direct effects on the thyroid. Early detection and therapy of this condition are important in order to avoid complications of thyroid disease such as cardiac arrhythmias.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.