ArticleThe international journal of biochemistry & cell biology2011
Multiple nuclear receptors may regulate hepatitis B virus biosynthesis during development.
Article in The international journal of biochemistry & cell biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- HBV and host metabolic crosstalk: Reprogramming pathways for viral replication and pathogenesis.Virologica Sinica · 2025Review
- Foxa deficiency restricts hepatitis B virus biosynthesis through epigenic silencing.Journal of virology · 2024Article
- Selective effect of β-catenin on nuclear receptor-dependent hepatitis B virus transcription and replication.Virology · 2022Article
- Article
- mTOR Signaling: The Interface Linking Cellular Metabolism and Hepatitis B Virus Replication.Virologica Sinica · 2021Review
- β-Catenin Signaling Regulates theJournal of virology · 2021Article
- Multifaceted Interaction Between Hepatitis B Virus Infection and Lipid Metabolism in Hepatocytes: A Potential Target of Antiviral Therapy for Chronic Hepatitis B.Frontiers in microbiology · 2021Review
- Peroxisome proliferator-activated receptor γ coactivator family members competitively regulate hepatitis b virus biosynthesis.Virology · 2019Article
- Steroid receptor coactivator 3 inhibits hepatitis B virus gene expression through activating Akt signaling to prevent HNF4α nuclear translocation.Cell & bioscience · 2019Article
- Micro-RNAs in hepatitis B virus-related chronic liver diseases and hepatocellular carcinoma.World journal of hepatology · 2018Review
- PGC1α Transcriptional Adaptor Function Governs Hepatitis B Virus Replication by Controlling HBcAg/p21 Protein-Mediated Capsid Formation.Journal of virology · 2017Article
- Hepatic deficiency of the pioneer transcription factor FoxA restricts hepatitis B virus biosynthesis by the developmental regulation of viral DNA methylation.PLoS pathogens · 2017Article
- Hepatitis B virus molecular biology and pathogenesis.Hepatoma research · 2016Article
- Hepatitis B Virus Stimulated Fibronectin Facilitates Viral Maintenance and Replication through Two Distinct Mechanisms.PloS one · 2016Article
- CRTC2 enhances HBV transcription and replication by inducing PGC1α expression.Virology journal · 2014Article
- MicroRNAs associated with HBV infection and HBV-related HCC.Theranostics · 2014Review
- GCN5 acetyltransferase inhibits PGC1α-induced hepatitis B virus biosynthesis.Virologica Sinica · 2013Article
- Inhibition of hepatitis B virus replication by the host zinc finger antiviral protein.PLoS pathogens · 2013Article
- Independent activation of hepatitis B virus biosynthesis by retinoids, peroxisome proliferators, and bile acids.Journal of virology · 2013Article
- Limited effects of bile acids and small heterodimer partner on hepatitis B virus biosynthesis in vivo.Journal of virology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Hepatitis B virus (HBV) replicates by the reverse transcription of the viral 3.5 kb pregenomic RNA. Therefore the level of expression of this transcript in the liver is a primary determinant of HBV biosynthesis. In vivo neonatal transcription of the HBV 3.5 kb pregenomic RNA is developmental regulated by hepatocyte nuclear factor 4α (HNF4α). In addition, viral biosynthesis in non-hepatoma cells can be supported directly by this nuclear receptor. However HBV transcription and replication can be supported by additional nuclear receptors including the retinoid X receptor α/peroxisome proliferator-activated receptor α (RXRα/PPARα), retinoid X receptor α/farnesoid X receptor α (RXRα/FXRα), liver receptor homolog 1 (LRH1) and estrogen-related receptors (ERR) in non-hepatoma cells. Therefore during neonatal liver development, HNF4α may progressively activate viral transcription and replication by binding directly to the proximal HNF4α recognition sequence within the nucleocapsid promoter. Alternatively, HNF4α may support viral biosynthesis in vivo indirectly by activating a network of liver-enriched nuclear receptors that, in combination, direct HBV 3.5 kb pregenomic RNA transcription and replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.