ArticleMechanisms of ageing and development2010
Maintenance of naïve CD8 T cells in nonagenarians by leptin, IGFBP3 and T3.
Article in Mechanisms of ageing and development, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Immune-related antigens, surface molecules and regulatory factors in human-derived mesenchymal stromal cells: the expression and impact of inflammatory priming.Stem cell reviews and reports · 2012Trial
- An age-related decrease in leptin contributes to CD8Cell reports. Medicine · 2025Article
- Signaling Pathways of the Insulin-like Growth Factor Binding Proteins.Endocrine reviews · 2023Article
- CD4 Phenotypes Are Associated with Reduced Expansion of Tumor-Infiltrating Lymphocytes in Melanoma Patients Treated with Adoptive Cell Therapy.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Age-related thymic involution: Mechanisms and functional impact.Aging cell · 2022Review
- Association of Single Nucleotide Polymorphisms inFrontiers in genetics · 2021Article
- Exploration of Potential Integrated Models of N6-Methyladenosine Immunity in Systemic Lupus Erythematosus by Bioinformatic Analyses.Frontiers in immunology · 2021Article
- Magnesium transporter 1 (MAGT1) deficiency causes selective defects inThe Journal of biological chemistry · 2019Article
- Dysregulation of T Follicular Helper Cells in Lupus.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Insulin-Like Growth Factor Binding Proteins in Autoimmune Diseases.Frontiers in endocrinology · 2018Review
- Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet.Journal of diabetes research · 2018Article
- Premature T Cell Senescence in Pediatric CKD.Journal of the American Society of Nephrology : JASN · 2017Article
- Immunologic Aging in Adults with Congenital Heart Disease: Does Infant Sternotomy Matter?Pediatric cardiology · 2015Article
- Effect of Diet and Exercise on the Peripheral Immune System in Young Balb/c Mice.BioMed research international · 2015Article
- Article
- Inverse associations between obesity indicators and thymic T-cell production levels in aging atomic-bomb survivors.PloS one · 2014Article
- Reversing T cell immunosenescence: why, who, and how.Age (Dordrecht, Netherlands) · 2013Review
- Increased vitamin D is associated with decline of naïve, but accumulation of effector, CD8 T cells during early aging.Advances in aging research · 2013Article
- Biochemical markers of aging for longitudinal studies in humans.Epidemiologic reviews · 2013Review
- Integration of immunity with physical and cognitive function in definitions of successful aging.Aging and disease · 2012Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 1 country.
Funding
Abstract
Research into the age-associated decline in the immune system has focused on the factors that contribute to the accumulation of senescent CD8 T cells. Less attention has been paid to the non-immune factors that may maintain the pool of naïve CD8 T cells. Here, we analyzed the status of the naïve CD8 T-cell population in healthy nonagenarians (>or=90-year-old), old (60-79-year-old), and young (20-34-year-old) subjects. Naïve CD8 T cells were defined as CD28(+)CD95(-) as this phenotype showed a strong co-expression of the CD45RA(+), CD45RO(-), and CD127(+) phenotypes. Although there was an age-associated decline in the percentage of CD28(+)CD95(-) CD8 T cells, the healthy nonagenarians maintained a pool of naïve CD28(+)CD95(-) cells that contained T-cell receptor excision circles (TREC)(+) cells. The percentages of naïve CD28(+)CD95(-) CD8 T cells in the nonagenarians correlated with the sera levels of insulin-like growth factor binding protein 3 (IGFBP3) and leptin. Higher levels of triiodothyronine (T3) negatively correlated with the accumulation of TREC(-)CD28(-)CD95(+) CD8 T cells from nonagenarians. These results suggest a model in which IGFBP3, leptin and T3 act as non-immune factors to maintain a larger pool of naïve CD8 T cells in healthy nonagenarians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.