Helicase multitasking in ribosome assembly.

Ulf-Peter Guenther, Eckhard Jankowsky

Abstract readComment

In one paragraph

Article in Molecular cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it

0cells of the map it votes in

6citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

An inhibitory segment within G-patch activators tunes Prp43-ATPase activity during ribosome assembly.Nature communications · 2024
Article
Host protein chaperones, RNA helicases and the ubiquitin network highlight the arms race for resources between tombusviruses and their hosts.Advances in virus research · 2020
Article
The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction.eLife · 2016
Article
RNA helicase proteins as chaperones and remodelers.Annual review of biochemistry · 2014
Review
The DEAD box protein Mrh4 functions in the assembly of the mitochondrial large ribosomal subunit.Cell metabolism · 2013
Article
Structural basis for the function of DEAH helicases.EMBO reports · 2010
Article

4 · The record

Corrections and comments

Comment on
Prp43 bound at different sites on the pre-rRNA performs distinct functions in ribosome synthesis.2009

5 · Who and what money

Authors and funding

2 authors.

Ulf-Peter GuentherDepartment of Biochemistry, Case Western Reserve University, Cleveland, OH 44106, USA.

Eckhard Jankowsky

Funding

Mechansim of DExH/D proteinsR01GM067700 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI JANKOWSKY, ECKHARD · 2003 to 2015

$4.2M

NIGMS NIH HHS R01 GM067700

6 · The paper itself

Abstract

In this issue of Molecular Cell, Bohnsack et al. (2009) identify multiple binding sites of the RNA helicase Prp43 on preribosomal RNA. The target regions suggest distinct functions of Prp43 in ribosome biogenesis.

Indexed as

DEAD-box RNA HelicasesModels, BiologicalProtein BindingRibosomesRNA, FungalRNA PrecursorsRNA, RibosomalSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDEAD-box RNA HelicasesPRP43 protein, S cerevisiaeRNA, FungalRNA PrecursorsRNA, RibosomalSaccharomyces cerevisiae Proteins

Identifiers

PMID19941813

DOI10.1016/j.molcel.2009.11.004

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.