ArticleNeurogastroenterology and motility2010
Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo.
Article in Neurogastroenterology and motility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 56 citations in OpenAlex.
- Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications.Life (Basel, Switzerland) · 2024Review
- The critical role of muscularis macrophages in modulating the enteric nervous system function and gastrointestinal motility.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2024Review
- Plasticity of colonic enteric nervous system following spinal cord injury in male and female rats.Neurogastroenterology and motility · 2023Article
- Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation.Comprehensive Physiology · 2023Article
- The enteric nervous system.Physiological reviews · 2023Review
- The Role of Short Chain Fatty Acids in Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2022Review
- Colonic Motility Is Improved by the Activation of 5-HTGastroenterology · 2021Article
- Structure, Function, and Pharmaceutical Ligands of 5-Hydroxytryptamine 2B Receptor.Pharmaceuticals (Basel, Switzerland) · 2021Review
- International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.Pharmacological reviews · 2021Review
- Serotonin and Dopamine Receptor Expression in Solid Tumours Including Rare Cancers.Pathology oncology research : POR · 2020Article
- Non-conventional features of peripheral serotonin signalling - the gut and beyond.Nature reviews. Gastroenterology & hepatology · 2017Review
- Serotonergic Mechanisms Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.Handbook of experimental pharmacology · 2017Review
- A Stochastic Algorithm for Generating Realistic Virtual Interstitial Cell of Cajal Networks.IEEE transactions on bio-medical engineering · 2015Article
- Gastrointestinal motility and its enteric actors in mechanosensitivity: past and present.Pflugers Archiv : European journal of physiology · 2015Review
- The type 7 serotonin receptor, 5-HT 7 , is essential in the mammary gland for regulation of mammary epithelial structure and function.BioMed research international · 2015Article
- Perivascular Interstitial Cells of Cajal in Human Colon.Cellular and molecular gastroenterology and hepatology · 2015Article
- Developmental changes in postnatal murine intestinal interstitial cell of Cajal network structure and function.Annals of biomedical engineering · 2014Article
- Numerical metrics for automated quantification of interstitial cell of Cajal network structural properties.Journal of the Royal Society, Interface · 2013Article
- Serotonin signalling in the gut--functions, dysfunctions and therapeutic targets.Nature reviews. Gastroenterology & hepatology · 2013Review
- Distribution of TMEM100 in the mouse and human gastrointestinal tract--a novel marker of enteric nerves.Neuroscience · 2013Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundNormal gastrointestinal motility requires intact networks of interstitial cells of Cajal (ICC). Interstitial cells of Cajal numbers are maintained by a balance between cell loss factors and survival/trophic/growth factors. Activation of 5-HT(2B) receptors expressed on ICC increases ICC proliferation in vitro. It is not known whether 5-HT(2B) receptors on ICC are activated in vivo. The aims of this study were to investigate if adult ICC proliferate, whether the proliferation of ICC in vivo is affected by knocking out the 5-HT(2B) receptor, and if alterations in proliferation affect ICC networks.
methodsProliferating ICC were identified by immunoreactivity for Ki67 in both the myenteric and deep muscular plexus regions of the jejunum in mice with a targeted insertion of a neomycin resistance cassette into the second coding exon of the htr2b receptor gene. KEY
resultsAdult ICC do proliferate. The number of proliferating ICC was lower in the myenteric plexus region of Htr2b(-/-) compared to Htr2b(+/+) mice. The volume of Kit-positive ICC was 30% lower in the myenteric plexus region and 40% lower in the deep muscular plexus region in Htr2b(-/-) mice where the number of ICC was also reduced. CONCLUSIONS & INFERENCES: Interstitial cells of Cajal proliferate in adult mice and activation of 5-HT(2B) receptors results in increased proliferation of ICC in vivo. Furthermore, lack of 5-HT(2B) receptor signaling reduces the density of ICC networks in mature mice. These data suggest that 5-HT(2B) receptor signaling is required for maintenance of ICC networks, adding 5-HT to the growing number of factors shown to regulate ICC networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.