ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2010
Androgenic regulation of ventral epithelial bud number and pattern in mouse urogenital sinus.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Prostatic lineage differentiation from human embryonic stem cells through inducible expression of NKX3-1.Stem cell research & therapy · 2024Article
- Pluripotent stem cell differentiation as an emerging model to study human prostate development.Stem cell research & therapy · 2020Review
- GLI3 resides at the intersection of hedgehog and androgen action to promote male sex differentiation.PLoS genetics · 2020Article
- Insight and Resources From a Study of the "Impact of Sex, Androgens, and Prostate Size on C57BL/6J Mouse Urinary Physiology.Toxicologic pathology · 2019Article
- Isolation and functional interrogation of adult human prostate epithelial stem cells at single cell resolution.Stem cell research · 2017Article
- RET-mediated glial cell line-derived neurotrophic factor signaling inhibits mouse prostate development.Development (Cambridge, England) · 2017Article
- An illustrated anatomical ontology of the developing mouse lower urogenital tract.Development (Cambridge, England) · 2015Article
- Glial cell line-derived neurotrophic factor induces cell proliferation in the mouse urogenital sinus.Molecular endocrinology (Baltimore, Md.) · 2015Article
- Androgen receptor DNA methylation regulates the timing and androgen sensitivity of mouse prostate ductal development.Developmental biology · 2014Article
- Sex specific retinoic acid signaling is required for the initiation of urogenital sinus bud development.Developmental biology · 2014Article
- Catalog of mRNA expression patterns for DNA methylating and demethylating genes in developing mouse lower urinary tract.Gene expression patterns : GEP · 2013Article
- Beta-catenin (CTNNB1) induces Bmp expression in urogenital sinus epithelium and participates in prostatic bud initiation and patterning.Developmental biology · 2013Article
- Wnt inhibitory factor 1 (Wif1) is regulated by androgens and enhances androgen-dependent prostate development.Endocrinology · 2012Article
- Visualization and quantification of mouse prostate development by in situ hybridization.Differentiation; research in biological diversity · 2012Article
- A high-resolution molecular atlas of the fetal mouse lower urogenital tract.Developmental dynamics : an official publication of the American Association of Anatomists · 2011Article
- Development of the human prostate.Differentiation; research in biological diversityReview
- Potential protective mechanisms of aryl hydrocarbon receptor (AHR) signaling in benign prostatic hyperplasia.Differentiation; research in biological diversityReview
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The ventral urogenital sinus (UGS) of control male mice has two rows of 3-4 prostatic buds at birth, but how androgens regulate ventral bud (VB) number and patterning is unclear. VBs in both sexes appeared to be a mixture of prostatic and urethral buds. UGSs from Tfm male and antiandrogen (flutamide)-exposed mice had small VBs, suggesting that initiation of some VBs is androgen independent. Tfm male mice are widely considered completely androgen insensitive yet their UGSs were 5alpha-dihydrotestosterone (DHT)- responsive. VBs (6-8) were generally distributed bimodally on the left-right axis at both minimal and normal male androgen signaling. Yet control females and DHT-exposed Tfm males had 13-14 VBs, whose left-right distribution was fairly uniform. These results suggest that VB number and distribution respond biphasically as androgen signaling increases from minimal, and that androgens regulate bud specification. Complete VB agenesis by the selective budding inhibitor 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) required high androgen signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.