ArticleJournal of neural transmission (Vienna, Austria : 1996)2010
The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed.
- More than meets the eye: mutation of the white gene in Drosophila has broad phenotypic and transcriptomic effects.Genetics · 2025Article
- Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases.Science advances · 2025Review
- Genetic bias in repeated evolution of pigment loss in cave populations of the Asellus aquaticus species complex.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Mating-induced increase of kynurenine in Drosophila ovary enhances starvation resistance of progeny.The Journal of biological chemistry · 2024Article
- On the benefits of the tryptophan metabolite 3-hydroxyanthranilic acid in Caenorhabditis elegans and mouse aging.Nature communications · 2023Article
- Extension of life span by down-regulation of enzymes catalyzing tryptophan conversion into kynurenine: Possible implications for mechanisms of aging.Experimental biology and medicine (Maywood, N.J.) · 2023Review
- Beyond the eye: Kynurenine pathway impairment causes midgut homeostasis dysfunction and survival and reproductive costs in blood-feeding mosquitoes.Insect biochemistry and molecular biology · 2022Article
- Kynurenine Pathway Metabolites in the Blood and Cerebrospinal Fluid Are Associated with Human Aging.Oxidative medicine and cellular longevity · 2022Article
- The effects of high-monosaccharide diets on development and biochemical composition of white-eyed mutant strain of house cricket (Acheta domesticus).Scientific reports · 2021Article
- Aging-related markers in rat urine revealed by dynamic metabolic profiling using machine learning.Aging · 2021Article
- Targeting metabolic pathways for extension of lifespan and healthspan across multiple species.Ageing research reviews · 2020Review
- A novel role for kynurenine 3-monooxygenase in mitochondrial dynamics.PLoS genetics · 2020Article
- Kynurenine pathway, NADExperimental gerontology · 2020Review
- Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond.Nature reviews. Drug discovery · 2019Review
- Characterisation of white and yellow eye colour mutant strains of house cricket, Acheta domesticus.PloS one · 2019Article
- Effect of Kynurenic Acid on Pupae Viability of Drosophila melanogaster cinnabar and cardinal Eye Color Mutants with Altered Tryptophan-Kynurenine Metabolism.Neurotoxicity research · 2018Article
- Minocycline treatment increases resistance to oxidative stress and extends lifespan inOncotarget · 2017Article
- Molecular signatures of longevity: Insights from cross-species comparative studies.Seminars in cell & developmental biology · 2017Review
- Multidrug transporters and organic anion transporting polypeptides protect insects against the toxic effects of cardenolides.Insect biochemistry and molecular biology · 2017Article
- Identification of an evolutionary conserved structural loop that is required for the enzymatic and biological function of tryptophan 2,3-dioxygenase.Scientific reports · 2016Article
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Abstract
Animal and human studies suggest that aging is associated with increased formation of kynurenine (KYN) from tryptophan (TRY). The rate-limiting factors of TRY-KYN metabolism are transmembrane transport of TRY, and activity of enzyme, TRY 2,3-dioxygenase (TDO2). Eye-color mutants, white (w1118) (impaired TRY transport) and vermilion (v48a and v2) (deficient TDO activity), were compared with wild-type Oregon-R (Ore-R) strain of Drosophila melanogaster. Female 1-day-old adult flies maintained on a standard medium, and acclimatized to 12-h light:12-h dark cycle were collected, and then regularly transferred to fresh medium every 3-4 days. The number of dead flies was recorded at the time of transfer. Forty flies were studied in each experimental group. The life span of w1118 (mean = 45.5 days), and v48a (mean = 47.6 days) and v2 (mean = 43.8 days), were significantly longer than of wild-type Ore-R flies (27.1 days) (p < 0.001, Logrank test). There were no differences in life span between w1118 and v48a and v2 mutants. Present results suggest that prolongation of life span may be associated with slow rate of KYN formation from TRY.
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