Evidence map›Paper›PMID 19941039›Full record

ReviewMolecular and cellular biochemistry2010

Receptor guanylyl cyclases in mammalian olfactory function.

Frank Zufall, Steven D Munger

Abstract readReview
In one paragraph

Review in Molecular and cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
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  15. Natriuretic hormones in brain function.Frontiers in endocrinology · 2014
    Review
  16. Article
  17. Article
  18. Pendrin, a novel transcriptional target of the uroguanylin system.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2013
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Frank ZufallDepartment of Physiology, University of Saarland School of Medicine, Gebäude 58, Kirrberger Str, 66421 Homburg, Germany. frank.zufall@uks.eu
Steven D Munger
Saarland University · DEUniversity of Maryland, Baltimore · US

Funding

Transduction mechanisms and CNS targets of GC-D neuronsR01DC005633 · NIDCD · UNIVERSITY OF MARYLAND BALTIMORE · PI MUNGER, STEVEN D · 2003 to 2014
$3.5M
NIDCD NIH HHS DC005633NIDCD NIH HHS R01 DC005633
6 · The paper itself

Abstract

The contributions of guanylyl cyclases to sensory signaling in the olfactory system have been unclear. Recently, studies of a specialized subpopulation of olfactory sensory neurons (OSNs) located in the main olfactory epithelium have provided important insights into the neuronal function of one receptor guanylyl cyclase, GC-D. Mice expressing reporters such as beta-galactosidase and green fluorescent protein in OSNs that normally express GC-D have allowed investigators to identify these neurons in situ, facilitating anatomical and physiological studies of this sparse neuronal population. The specific perturbation of GC-D function in vivo has helped to resolve the role of this guanylyl cyclase in the transduction of olfactory stimuli. Similar approaches could be useful for the study of the orphan receptor GC-G, which is expressed in another distinct subpopulation of sensory neurons located in the Grueneberg ganglion. In this review, we discuss key findings that have reinvigorated the study of guanylyl cyclase function in the olfactory system.

Indexed as

Olfactory PathwaysSignal TransductionAnimalsHumansOlfactory MucosaOlfactory Receptor NeuronsReceptors, Guanylate Cyclase-CoupledReceptors, Guanylate Cyclase-Coupled

Identifiers

PMID19941039
PMCPMC2809823
OpenAlexW1984474897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.