ArticleInternational archives of allergy and immunology2010
A Six-SNP haplotype of ADAM33 is associated with asthma in a population of Cartagena, Colombia.
Article in International archives of allergy and immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis.Respiratory research · 2019Pooled it
- Association between ADAM33 T1 polymorphism and susceptibility to asthma in Asians.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Pooled it
- Allergy-specific Phenome-Wide Association Study for Immunogenes in Turkish Children.Scientific reports · 2016Trial
- ADAM33's Role in Asthma Pathogenesis: An Overview.International journal of molecular sciences · 2024Review
- Association betweenDiagnostics (Basel, Switzerland) · 2023Article
- The Association of IgE Levels withJournal of personalized medicine · 2021Article
- Haplotype analysis ofThe Indian journal of medical research · 2019Article
- Association of ADAM33 gene polymorphisms with asthma in Mongolian and Han groups in Inner Mongolia.Saudi journal of biological sciences · 2018Article
- Single nucleotide polymorphisms in asthma candidate genesAsthma research and practice · 2018Article
- Genetic polymorphisms and asthma: findings from a case-control study in the Madeira island population.Biological research · 2014Article
- Association of ADAM33 gene polymorphisms with allergic asthma.Iranian journal of basic medical sciences · 2014Article
- Associations of genetic variants in ADAM33 and TGF-β1 genes with childhood asthma risk.Biomedical reports · 2014Article
- Association study on ADAM33 polymorphisms in mite-sensitized persistent allergic rhinitis in a Chinese population.PloS one · 2014Article
- ADAM33 polymorphisms are associated with asthma and a distinctive palm dermatoglyphic pattern.Molecular medicine reports · 2013Article
- Association of ADAM33 gene polymorphisms with asthma in the Uygur population of China.Biomedical reports · 2013Article
- Asthma in children and adolescents: a comprehensive approach to diagnosis and management.Clinical reviews in allergy & immunology · 2012Review
- Whole-genome resequencing of two elite sires for the detection of haplotypes under selection in dairy cattle.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Association of ADAM33 gene polymorphisms with adult-onset asthma and its severity in an Indian adult population.Journal of genetics · 2011Article
- Role of ADAM33 gene and associated single nucleotide polymorphisms in asthma.Allergy & rhinology (Providence, R.I.) · 2011Article
- T1 and T2 ADAM33 single nucleotide polymorphisms and the risk of childhood asthma in a Saudi Arabian population: a pilot study.Annals of Saudi medicineArticle
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundA disintegrin and metalloprotein-33 (ADAM33) participates in the bronchial remodeling process in asthma, and genetic analyses pointed it out as a candidate gene in asthma.
methodsTo analyze the association between ADAM33 and asthma and total and mite-specific IgE levels in a population of the Caribbean Coast of Colombia, we genotyped 6 single-nucleotide polymorphisms of ADAM33 in 429 asthmatics, 401 controls and 116 family trios using fluorogenic probes. Total and specific IgE against Blomia tropicalis and Dermatophagoides pteronyssinus were determined by ELISA. Case-control and family-based analyses were performed. Case-control association analyses were corrected by population stratification using a set of 52 ancestry-informative markers.
resultsEight common haplotypes were identified; among them, H4 (GCAGGG) was associated with asthma in the family group (Z score: -2.049, p = 0.04). We also found an association between the TT genotype of ST+7 and asthma in the case-control study (p = 0.05) that disappeared after correcting for multiple testing. In the family-based analysis, this genotype was a risk factor for asthma (p = 0.01), high total IgE (Z score: 2.546, p = 0.01) and high specific IgE against B. tropicalis (p = 0.02) and D. pteronyssinus (Z score: 2.414, p = 0.01). V4 was associated with specific IgE against B. tropicalis (p = 0.03); T2 with asthma (p = 0.03), high total IgE (p = 0.02) and IgE against D. pteronyssinus (p = 0.03) and T1 with high total IgE (p = 0.04). None of these associations was maintained after correction for multiple testing.
conclusionsOur findings suggest a relevant role of ADAM33 in thepathogenesis of asthma in this population.
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