ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Dopamine-stimulated dephosphorylation of connexin 36 mediates AII amacrine cell uncoupling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.
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Who cites it
121 citing papers in PubMed, 200 citations in OpenAlex.
- Defining the electrical synapse.Nature reviews. Neuroscience · 2026Review
- Optogenetic Isolation of the Amacrine Cell-OFF Bipolar Cell Synapse Shows Selective D1R Control of Glycinergic Transmission.bioRxiv : the preprint server for biology · 2026Article
- Uncovering the electrical synapse proteome in retinal neurons via in vivo proximity labeling.eLife · 2026Article
- Activity induced GEM-4/Copine expression inhibits gap junctions and promotes thermosensory plasticity.bioRxiv : the preprint server for biology · 2026Article
- Junctional conductance of retinal AII amacrine cell electrical synapses is decreased by NMDA receptors.The Journal of physiology · 2026Article
- Activation of Dopamine D1 Receptors at the Axon Initial Segment-Like Process of Retinal AII Amacrine Cells Modulates Action Potential Firing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Inter-platelet communication driving thrombus formation is regulated by extracellular calpain-1 cleavage of connexin 62.Haematologica · 2025Article
- Retinal fundus imaging as biomarker for ADHD using machine learning for screening and visual attention stratification.NPJ digital medicine · 2025Article
- Dopamine receptors D1, D2, and D4 modulate electrical synapses and excitability in the thalamic reticular nucleus.Journal of neurophysiology · 2025Article
- Nitric oxide modulates contrast suppression in a subset of mouse retinal ganglion cells.eLife · 2025Article
- Regulation of Cx36 trafficking through the early secretory pathway by COPII cargo receptors and Grasp55.Cellular and molecular life sciences : CMLS · 2024Article
- Retinal bipolar cells borrow excitability from electrically coupled inhibitory interneurons to amplify excitatory synaptic transmission.bioRxiv : the preprint server for biology · 2024Article
- Neuropeptide Modulation Enables Biphasic Internetwork Coordination via a Dual-Network Neuron.eNeuro · 2024Article
- Trafficking of Connexin36 (Cx36) in the early secretory pathway.bioRxiv : the preprint server for biology · 2024Article
- Diurnal gene expression patterns in retina and choroid distinguish myopia progression from myopia onset.PloS one · 2024Article
- Functional maturation of the rod bipolar to AII-amacrine cell ribbon synapse in the mouse retina.Cell reports · 2023Article
- Restoring connexin-36 function in diabetogenic environments precludes mouse and human islet dysfunction.The Journal of physiology · 2023Article
- Article
- Extrinsic and Intrinsic Factors Determine Expression Levels of Gap Junction-Forming Connexins in the Mammalian Retina.Biomolecules · 2023Review
- The Role of Retinal Dysfunction in Myopia Development.Cellular and molecular neurobiology · 2023Review
61 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Gap junction proteins form the substrate for electrical coupling between neurons. These electrical synapses are widespread in the CNS and serve a variety of important functions. In the retina, connexin 36 (Cx36) gap junctions couple AII amacrine cells and are a requisite component of the high-sensitivity rod photoreceptor pathway. AII amacrine cell coupling strength is dynamically regulated by background light intensity, and uncoupling is thought to be mediated by dopamine signaling via D(1)-like receptors. One proposed mechanism for this uncoupling involves dopamine-stimulated phosphorylation of Cx36 at regulatory sites, mediated by protein kinase A. Here we provide evidence against this hypothesis and demonstrate a direct relationship between Cx36 phosphorylation and AII amacrine cell coupling strength. Dopamine receptor-driven uncoupling of the AII network results from protein kinase A activation of protein phosphatase 2A and subsequent dephosphorylation of Cx36. Protein phosphatase 1 activity negatively regulates this pathway. We also find that Cx36 gap junctions can exist in widely different phosphorylation states within a single neuron, implying that coupling is controlled at the level of individual gap junctions by locally assembled signaling complexes. This kind of synapse-by-synapse plasticity allows for precise control of neuronal coupling, as well as cell-type-specific responses dependent on the identity of the signaling complexes assembled.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.