ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2009
Tripartite purinergic modulation of central respiratory networks during perinatal development: the influence of ATP, ectonucleotidases, and ATP metabolites.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 58 citations in OpenAlex.
- Review
- Purinergic signaling mediates neuroglial interactions to modulate sighs.Nature communications · 2023Article
- Maternal Methadone Destabilizes Neonatal Breathing and Desensitizes Neonates to Opioid-Induced Respiratory Frequency Depression.Frontiers in physiology · 2021Article
- Thrombin action on astrocytes in the hindbrain of the rat disrupts glycemic and respiratory control.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- The Purinome and the preBötzinger Complex - A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response.Frontiers in cellular neuroscience · 2019Article
- Julius H. Comroe Distinguished Lecture: Interdependence of neuromodulators in the control of breathing.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Review
- Morphometric analysis of astrocytes in brainstem respiratory regions.The Journal of comparative neurology · 2018Article
- Release of ATP by pre-Bötzinger complex astrocytes contributes to the hypoxic ventilatory response via a CaThe Journal of physiology · 2018Article
- Advances in cellular and integrative control of oxygen homeostasis within the central nervous system.The Journal of physiology · 2018Review
- Review
- Gliotransmission and adenosinergic modulation: insights from mammalian spinal motor networks.Journal of neurophysiology · 2017Review
- ATP and astrocytes play a prominent role in the control of the respiratory pattern generator in the lamprey.The Journal of physiology · 2017Article
- On the existence of a central respiratory oxygen sensor.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Review
- Adenosine-mediated modulation of ventral horn interneurons and spinal motoneurons in neonatal mice.Journal of neurophysiology · 2015Article
- Functional Oxygen Sensitivity of Astrocytes.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine.PloS one · 2015Article
- Glial TLR4 signaling does not contribute to opioid-induced depression of respiration.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- P2Y1 receptor-mediated potentiation of inspiratory motor output in neonatal rat in vitro.The Journal of physiology · 2014Article
- Neurochemical and electrical modulation of the locus coeruleus: contribution to CO2drive to breathe.Frontiers in physiology · 2014Review
- Regulation of adenosine levels during cerebral ischemia.Acta pharmacologica Sinica · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
Abstract
ATP released during hypoxia from the ventrolateral medulla activates purinergic receptors (P2Rs) to attenuate the secondary hypoxic depression of breathing by a mechanism that likely involves a P2Y(1)R-mediated excitation of preBötzinger complex (preBötC) inspiratory rhythm-generating networks. In this study, we used rhythmically active in vitro preparations from embryonic and postnatal rats and ATP microinjection into the rostral ventral respiratory group (rVRG)/preBötC to reveal that these networks are sensitive to ATP when rhythm emerges at embryonic day 17 (E17). The peak frequency elicited by ATP at E19 and postnatally was the same ( approximately 45 bursts/min), but relative sensitivity was threefold greater at E19, reflecting a lower baseline frequency (5.6 +/- 0.9 vs 19.0 +/- 1.3 bursts/min). Combining microinjection techniques with ATP biosensors revealed that ATP concentration in the rVRG/preBötC falls rapidly as a result of active processes and closely correlates with inspiratory frequency. A phosphate assay established that preBötC-containing tissue punches degrade ATP at rates that increase perinatally. Thus, the agonist profile [ATP/ADP/adenosine (ADO)] produced after ATP release in the rVRG/preBötC will change perinatally. Electrophysiology further established that the ATP metabolite ADP is excitatory and that, in fetal but not postnatal animals, ADO at A(1) receptors exerts a tonic depressive action on rhythm, whereas A(1) antagonists extend the excitatory action of ATP on inspiratory rhythm. These data demonstrate that ATP is a potent excitatory modulator of the rVRG/preBötC inspiratory network from the time it becomes active and that ATP actions are determined by a dynamic interaction between the actions of ATP at P2 receptors, ectonucleotidases that degrade ATP, and ATP metabolites on P2Y and P1 receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.