ArticleThe Journal of biological chemistry2010
IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 50 citations in OpenAlex.
- Breast cancer patient-derived microtumors resemble tumor heterogeneity and enable protein-based stratification and functional validation of individualized drug treatment.Journal of experimental & clinical cancer research : CR · 2023Article
- IκB kinase-ε-mediated phosphorylation triggers IRF-1 degradation in breast cancer cells.Neoplasia (New York, N.Y.) · 2020Article
- Distinct Roles of mTOR Targets S6K1 and S6K2 in Breast Cancer.International journal of molecular sciences · 2020Review
- Prognostic significance of preoperative IKBKE expression in esophageal squamous cell carcinoma.OncoTargets and therapy · 2018Article
- mTOR/Raptor signaling is critical for skeletogenesis in mice through the regulation of Runx2 expression.Cell death and differentiation · 2017Article
- Detection of IKKε by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis.BMC cancer · 2017Article
- Beta protein 1 homeoprotein induces cell growth and estrogen-independent tumorigenesis by binding to the estrogen receptor in breast cancer.Oncotarget · 2016Article
- Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines.Redox biology · 2015Article
- Diallyl disulfide inhibits TNFα induced CCL2 release through MAPK/ERK and NF-Kappa-B signaling.Cytokine · 2015Article
- Glyceollin, a novel regulator of mTOR/p70S6 in estrogen receptor positive breast cancer.The Journal of steroid biochemistry and molecular biology · 2015Article
- Minireview: Tipping the balance: ligand-independent activation of steroid receptors.Molecular endocrinology (Baltimore, Md.) · 2015Review
- Aurora-A is a determinant of tamoxifen sensitivity through phosphorylation of ERα in breast cancer.Oncogene · 2014Article
- Elevated expression of TANK-binding kinase 1 enhances tamoxifen resistance in breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy.Nature reviews. Cancer · 2014Review
- Phosphorylation: a fundamental regulator of steroid receptor action.Trends in endocrinology and metabolism: TEM · 2013Review
- Adamantyl arotinoids that inhibit IκB kinase α and IκB kinase β.ChemMedChem · 2013Article
- Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen.Oncology letters · 2013Article
- IκB kinase ε (IKKε): a therapeutic target in inflammation and cancer.Biochemical pharmacology · 2013Review
- A MicroRNA196a2* and TP63 circuit regulated by estrogen receptor-α and ERK2 that controls breast cancer proliferation and invasiveness properties.Hormones & cancer · 2013Article
- IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer.Oncogene · 2013Article
Corrections and comments
- Retraction · 2016-10-21Duplication of Data · Duplication of/in Image · Falsification/Fabrication of Data · Falsification/Fabrication of Image · Investigation by Company/Institution ·
- Retracted
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
IKKepsilon has recently been identified as a breast cancer oncogene. Elevated levels of IKKepsilon are associated with cell survival and growth. Here, we show that IKKepsilon interacts with and phosphorylates estrogen receptor alpha (ERalpha) on serine 167 in vitro and in vivo. As a result, IKKepsilon induces ERalpha transactivation activity and enhances ERalpha binding to DNA. Cyclin D1, a major target of ERalpha, is transcriptionally up-regulated by IKKepsilon in a phospho-ERalpha-Ser-167-dependent manner. Further, overexpression of IKKepsilon induces tamoxifen resistance, whereas knockdown of IKKepsilon sensitizes cells to tamoxifen-induced cell death. These data suggest that ERalpha is a bona fide substrate of IKKepsilon and IKKepsilon plays an important role in tamoxifen resistance. Thus, IKKepsilon represents a critical therapeutic target in breast cancer.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.