Evidence map›Paper›PMID 19940063›Full record

ArticleThe Journal of general virology2010

Characterization of a novel wood mouse virus related to murid herpesvirus 4.

David J Hughes, Anja Kipar, Steven G Milligan, Charles Cunningham, Mandy Sanders, Michael A Quail, Marie-Adele Rajandream, Stacey Efstathiou, Rory J Bowden, Claude Chastel and 5 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of general virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Identification of Novel TAT-I24-Related Peptides with Antiviral Activities.International journal of molecular sciences · 2025
    Article
  3. Review
  4. Article
  5. Immune Control ofViral immunology · 2020
    Article
  6. Article
  7. Review
  8. Tick-Borne Transmission of Murine Gammaherpesvirus 68.Frontiers in cellular and infection microbiology · 2017
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Herpesvirus systematics.Veterinary microbiology · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

David J HughesSchool of Infection and Host Defence, University of Liverpool, Liverpool L69 3GA, UK.
Anja Kipar
Steven G Milligan
Charles Cunningham
Mandy Sanders
Michael A Quail
Marie-Adele Rajandream
Stacey Efstathiou
Rory J Bowden
Claude Chastel
Malcolm Bennett
Jeffery T Sample
Bart Barrell
Andrew J Davison
James P Stewart
University of Glasgow · GBUniversity of Liverpool · GBWellcome Sanger Institute · GBInstitut de Virologie · FRPennsylvania State University · USUniversity of Cambridge · GB

Funding

Murine Model of Gammaherpesvirus LatencyR01CA090208 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI SAMPLE, JEFFERY T · 2001 to 2005
$1.4M
Medical Research Council MC_U130184136Medical Research Council MC_UU_12014/3NCI NIH HHS CA090208NCI NIH HHS R01 CA090208Wellcome Trust
6 · The paper itself

Abstract

Two novel gammaherpesviruses were isolated, one from a field vole (Microtus agrestis) and the other from wood mice (Apodemus sylvaticus). The genome of the latter, designated wood mouse herpesvirus (WMHV), was completely sequenced. WMHV had the same genome structure and predicted gene content as murid herpesvirus 4 (MuHV4; murine gammaherpesvirus 68). Overall nucleotide sequence identity between WMHV and MuHV4 was 85 % and most of the 10 kb region at the left end of the unique region was particularly highly conserved, especially the viral tRNA-like sequences and the coding regions of genes M1 and M4. The partial sequence (71 913 bp) of another gammaherpesvirus, Brest herpesvirus (BRHV), which was isolated ostensibly from a white-toothed shrew (Crocidura russula), was also determined. The BRHV sequence was 99.2 % identical to the corresponding portion of the WMHV genome. Thus, WMHV and BRHV appeared to be strains of a new virus species. Biological characterization of WMHV indicated that it grew with similar kinetics to MuHV4 in cell culture. The pathogenesis of WMHV in wood mice was also extremely similar to that of MuHV4, except for the absence of inducible bronchus-associated lymphoid tissue at day 14 post-infection and a higher load of latently infected cells at 21 days post-infection.

Indexed as

Amino Acid SequenceAnimalsArvicolinaeBase SequenceDNA, ViralGammaherpesvirinaeGenome, ViralMolecular Sequence DataMurinaeRhadinovirusViral Matrix ProteinsDNA, ViralViral Matrix Proteins

Identifiers

PMID19940063
PMCPMC2888160
OpenAlexW2161148942

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.