ArticleProceedings. Biological sciences2010
Mixed genotype transmission bodies and virions contribute to the maintenance of diversity in an insect virus.
Article in Proceedings. Biological sciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 58 citations in OpenAlex.
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- Presence of Spodoptera frugiperda Multiple Nucleopolyhedrovirus (SfMNPV) Occlusion Bodies in Maize Field Soils of Mesoamerica.Insects · 2023Article
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- Viral Aggregation: The Knowns and Unknowns.Viruses · 2022Review
- Generation of Variability inViruses · 2021Article
- CpGV-M Replication in Type I Resistant Insects: Helper Virus and Order of Ingestion Are Important.Viruses · 2021Article
- Mixtures of Insect-Pathogenic Viruses in a Single Virion: towards the Development of Custom-Designed Insecticides.Applied and environmental microbiology · 2021Article
- Nucleopolyhedrovirus Coocclusion Technology: A New Concept in the Development of Biological Insecticides.Frontiers in microbiology · 2021Review
- Genetic variants in Argentinean isolates of Spodoptera frugiperda Multiple Nucleopolyhedrovirus.Virus genes · 2020Article
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- Membrane-Associated Enteroviruses Undergo Intercellular Transmission as Pools of Sibling Viral Genomes.Cell reports · 2019Article
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- Importance of the Host Phenotype on the Preservation of the Genetic Diversity in Codling Moth Granulovirus.Viruses · 2019Article
- Why viruses sometimes disperse in groups?Virus evolution · 2019Review
- Collective properties of viral infectivity.Current opinion in virology · 2018Review
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An insect nucleopolyhedrovirus naturally survives as a mixture of at least nine genotypes. Infection by multiple genotypes results in the production of virus occlusion bodies (OBs) with greater pathogenicity than those of any genotype alone. We tested the hypothesis that each OB contains a genotypically diverse population of virions. Few insects died following inoculation with an experimental two-genotype mixture at a dose of one OB per insect, but a high proportion of multiple infections were observed (50%), which differed significantly from the frequencies predicted by a non-associated transmission model in which genotypes are segregated into distinct OBs. By contrast, insects that consumed multiple OBs experienced higher mortality and infection frequencies did not differ significantly from those of the non-associated model. Inoculation with genotypically complex wild-type OBs indicated that genotypes tend to be transmitted in association, rather than as independent entities, irrespective of dose. To examine the hypothesis that virions may themselves be genotypically heterogeneous, cell culture plaques derived from individual virions were analysed to reveal that one-third of virions was of mixed genotype, irrespective of the genotypic composition of the OBs. We conclude that co-occlusion of genotypically distinct virions in each OB is an adaptive mechanism that favours the maintenance of virus diversity during insect-to-insect transmission.
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