ArticleThe Journal of pediatrics2010
In utero iron status and auditory neural maturation in premature infants as evaluated by auditory brainstem response.
Article in The Journal of pediatrics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 109 citations in OpenAlex.
- Iron Deficiency and Iron Homeostasis in Low Birth Weight Preterm Infants: A Systematic Review.Nutrients · 2019Pooled it
- Enteral iron dose effect on iron storage, intestinal barrier, and gut microbiome in preterm infants: a randomized clinical trial.The American journal of clinical nutrition · 2026Trial
- Enteral Iron Supplementation in Infants Born Extremely Preterm and its Positive Correlation with Neurodevelopment; Post Hoc Analysis of the Preterm Erythropoietin Neuroprotection Trial Randomized Controlled Trial.The Journal of pediatrics · 2021Trial
- Effect of High-Dose Erythropoietin on Blood Transfusions in Extremely Low Gestational Age Neonates: Post Hoc Analysis of a Randomized Clinical Trial.JAMA pediatrics · 2020Trial
- Low-Dose Iron Supplementation in Infancy Modestly Increases Infant Iron Status at 9 Mo without Decreasing Growth or Increasing Illness in a Randomized Clinical Trial in Rural China.The Journal of nutrition · 2016Trial
- Prenatal Iron Supplementation Reduces Maternal Anemia, Iron Deficiency, and Iron Deficiency Anemia in a Randomized Clinical Trial in Rural China, but Iron Deficiency Remains Widespread in Mothers and Neonates.The Journal of nutrition · 2015Trial
- Iron supplementation in premature infants using the zinc protoporphyrin to heme ratio: short- and long-term outcomes.Journal of perinatology : official journal of the California Perinatal Association · 2013Trial
- Association between reticulocyte hemoglobin content (RetHe) and neurodevelopmental outcomes in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Article
- Association between maternal anemia and cord blood hemoglobin and ferritin concentrations in newborns: a Single-center study in Turkey.BMC pregnancy and childbirth · 2025Article
- Maternal Prenatal Psychological Stress and Iron Levels in the Fetal Brain.Developmental psychobiology · 2025Article
- The transfusion of prematures early school age follow-up (TOP 5): protocol for a longitudinal cohort study.BMC pediatrics · 2025Article
- Early life stress and iron metabolism in developmental psychoneuroimmunology.Brain, behavior, & immunity - health · 2024Article
- Biomarkers of Brain Dysfunction in Perinatal Iron Deficiency.Nutrients · 2024Review
- Anemia, Iron Supplementation, and the Brain.Clinics in perinatology · 2023Review
- Biology of Anemia: A Public Health Perspective.The Journal of nutrition · 2023Article
- Association of Cord Ferritin Levels with Brain Stem Evoked Response Audiometry in Newborns.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2023Article
- The Interaction between Psychological Stress and Iron Status on Early-Life Neurodevelopmental Outcomes.Nutrients · 2023Review
- The importance of iron deficiency in pregnancy on fetal, neonatal, and infant neurodevelopmental outcomes.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2023Review
- Differentiation between fetal and postnatal iron deficiency in altering brain substrates of cognitive control in pre-adolescence.BMC medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether cord ferritin (CF) concentration, an index of in utero iron status, is associated with auditory neural maturation in premature infants. STUDY
designA prospective cohort study was performed to compare auditory neural maturation in infants with latent iron deficiency (CF 11-75 ng/mL) and infants with normal iron status (CF > 75 ng/mL) at birth. Our inclusion criteria were infants of 27-33 weeks gestational age who were admitted to the neonatal intensive care unit between July 2007 and November 2008 within 12 hours after birth and had cord blood collected. Infants with TORCH infections (toxoplasmosis, other infections, rubella, cytomegalovirus infection, and herpes simplex), chromosomal disorders, craniofacial anomalies, culture-proven sepsis, and/or unstable conditions were excluded. CF level was measured using a chemiluminescence immunoassay method. Bilateral monaural auditory brainstem evoked response (ABR) was assessed using 80-dB nHL click stimuli at a repetition rate of 29.9/seconds within 48 hours after birth.
resultsOf the 80 infants studied, 35 had latent iron deficiency. After controlling for confounders, the infants with latent iron deficiency had significantly prolonged absolute wave latencies I, III, and V and decreased frequency of mature ABR waveforms compared with the infants with normal iron status.
conclusionPremature infants with in utero latent iron deficiency have abnormal auditory neural maturation compared with infants with normal in utero iron status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.