ArticlePlant signaling & behavior2009
Evidence for a role of hexokinases as conserved glucose sensors in both monocot and dicot plant species.
Article in Plant signaling & behavior, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Intra-Relations of Biochemical Profiles Defining the Germination Potential of Medium-Term Cold-Stored Maize (Plants (Basel, Switzerland) · 2026Article
- Sugar sensing in C4 source leaves: a gap that needs to be filled.Journal of experimental botany · 2024Review
- Spatial expression patterns of genes encoding sugar sensors in leaves of C4 and C3 grasses.Annals of botany · 2023Article
- Prunus Hexokinase 3 genes alter primary C-metabolism and promote drought and salt stress tolerance in Arabidopsis transgenic plants.Scientific reports · 2021Article
- Differences in the Formation Mechanism of Giant Colonies in TwoInternational journal of molecular sciences · 2020Article
- The Sugar-Signaling Hub: Overview of Regulators and Interaction with the Hormonal and Metabolic Network.International journal of molecular sciences · 2018Review
- Pentatricopeptide-repeat family protein RF6 functions with hexokinase 6 to rescue rice cytoplasmic male sterility.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Sugar regulation of SUGAR TRANSPORTER PROTEIN 1 (STP1) expression in Arabidopsis thaliana.Journal of experimental botany · 2015Article
- Differential anoxic expression of sugar-regulated genes reveals diverse interactions between sugar and anaerobic signaling systems in rice.Molecules and cells · 2013Article
- Hexose kinases and their role in sugar-sensing and plant development.Frontiers in plant science · 2013Article
- Rare sugar D-allose suppresses gibberellin signaling through hexokinase-dependent pathway in Oryza sativa L.Planta · 2011Article
- Exploring the neutral invertase-oxidative stress defence connection in Arabidopsis thaliana.Journal of experimental botany · 2011Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of the hexokinases (HXKs) as glucose (Glc) sensors has been mainly demonstrated for Arabidopsis (Arabidopsis thaliana) HXK1 (AtHXK1) but has yet to be shown in other plant species. In our recent publication, we reported that two rice (Oryza sativa) HXKs, OsHXK5 and OsHXK6, also function as Glc sensors. These two enzymes harbor both mitochondrial targeting peptides (mTPs) and nuclear localization signals (NLSs), and we confirmed their dual-targeting ability to nuclei and mitochondria using GFP fusion experiments. Consistently, it has been previously known that AtHXK1 is predominantly associated with mitochondria but is also present in nuclei in vivo at appreciable levels. Notably, the expression of OsHXK5, OsHXK6, or their catalytically inactive mutant alleles complemented the Arabidopsis glucose insensitive2 (gin2) mutant. In addition, transgenic rice plants overexpressing OsHXK5 or OsHXK6 exhibited hypersensitive plant growth retardation and enhanced repression of the Rubisco small subunit (RbcS) gene in response to glucose treatment. Our results thus provided evidence that OsHXK5 and OsHXK6 can function as glucose sensors in rice. Hence, the available current data suggest that the role of the HXKs as Glc sensors may be conserved in both monocot and dicot plant species, and that the nuclear localization of AtHXK1, OsHXK5 and OsHXK6 may be critical for Glc sensing and signaling.
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