ArticleClinical cardiology2009
Clinical prognostic significance of plasma cystatin C levels among patients with acute coronary syndrome.
Article in Clinical cardiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association Between Increased Levels of Cystatin C and the Development of Cardiovascular Events or Mortality: A Systematic Review and Meta-Analysis.Arquivos brasileiros de cardiologia · 2018Pooled it
- Impact of N-acetylcysteine on contrast-induced nephropathy defined by cystatin C in patients with ST-elevation myocardial infarction undergoing primary angioplasty.Clinical research in cardiology : official journal of the German Cardiac Society · 2011Trial
- Performance of Colorimetric Lateral Flow Immunoassays for Renal Function Evaluation with Human Serum Cystatin C.Biosensors · 2025Article
- The role of inflammation, oxidation and Cystatin-C in the pathophysiology of polycystic ovary syndrome.Turkish journal of obstetrics and gynecology · 2022Article
- Clinical utility of serum cystatin C for prediction of multi-vessel disease by coronary angiography in type 2 diabetes mellitus patients with normal renal function.BMC cardiovascular disorders · 2020Article
- Red blood cell distribution width as long-term prognostic markers in patients with coronary artery disease undergoing percutaneous coronary intervention.Lipids in health and disease · 2019Article
- High cystatin C levels predict long-term mortality in patients with ST-segment elevation myocardial infarction undergoing late percutaneous coronary intervention: A retrospective study.Clinical cardiology · 2019Observational
- Association of serum cystatin C levels with acute coronary syndrome in patients of advanced age.The Journal of international medical research · 2019Article
- Correlations of serum cystatin C and glomerular filtration rate with vascular lesions and severity in acute coronary syndrome.BMC cardiovascular disorders · 2017Article
- Association of serum cystatin C levels with myocardial perfusion and cardiac functional recovery in patients with anterior wall ST elevation myocardial infarction treated with primary coronary intervention.Heart and vessels · 2016Article
- Cystatin C: A prognostic marker after myocardial infarction in patients without chronic kidney disease.Journal of the Saudi Heart Association · 2016Article
- Glomerular filtration rate (GFR) during and after STEMI: a single-centre, methodological study comparing estimated and measured GFR.BMJ open · 2015Article
- Correlation between serum cystatin C level and elderly hypertensive patients combined coronary heart disease.International journal of clinical and experimental medicine · 2015Article
- Clinical outcome in patients with acute coronary syndrome and outward remodeling is associated with a predominant inflammatory response.BMC research notes · 2014Article
- Long-term prognostic impact of cystatin C on acute coronary syndrome octogenarians with diabetes mellitus.Cardiovascular diabetology · 2013Article
- Cystatin C in Acute Coronary Syndrome.EJIFCC · 2013Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis article aims to investigate the changes of plasma cystatin C concentration (PcyC), and to evaluate the relationship between PcyC and acute coronary syndrome.
methodsA total of 126 consecutive patients with coronary artery disease (CAD) were enrolled in this study, consisting of 34 patients with stable angina pectoris (SAP), 56 patients with unstable angina pectoris (UAP), 36 patients with acute myocardial infarction (AMI), and 34 healthy subjects as controls. Plasma cystatin C, high sensitivity C-reactive protein (hs-CRP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), and uric acid (UA) in all subjects were determined. All patients were followed up for 6 months and adverse cardiovascular events were recorded.
resultsPlasma cystatin C was elevated in CAD. Cystatin C levels were significantly higher in UAP patients than those in SAP patients and controls (2013.83 +/- 633.85 ng/mL vs 1348.41 +/- 369.62 ng/mL and 1509.99 +/- 408.65 ng/mL, P < 0.05), but were much lower than those in AMI patients (2013.83 +/- 633.85 ng/mL vs 2873.55 +/- 1149.48 ng/mL, P < 0.05). Patients with AMI also exhibited significantly higher cystatin C levels than SAP patients and the control group (2873.55 +/- 1149.48 ng/mL vs 1348.41 +/- 369.62 ng/mL and 1509.99 +/- 408.65 ng/mL, P < 0.01). Much higher hs-CRP concentrations were found in UAP patients (1.58 +/- 2.81 mg/L, P < 0.05) and AMI patients (20.68 +/- 18.98 mg/L, P < 0.01). Cystatin C was positively and significantly correlated with age, hs-CRP, white blood cells (WBC), creatinine, and UA (r > 0, P < 0.05), whereas a significantly negative correlation was observed with HDL-C (r = - 0.227, P < 0.05). These coefficients were clearly high for creatinine (r = + 0.612) and WBC (r = + 0.459). During the 6 month follow-up, 26 patients were found with adverse cardiovascular events and had significantly higher cystatin C levels than the 22 control patients at admission (2356.73 +/- 897.64 ng/mL vs 1469.51 +/- 574.83 ng/mL, P < 0.01).
conclusionsCystatin C plays an important role in the development of CAD and PcyC is a strong predictor for risk of cardiovascular events.
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