ArticleAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics2010
Linkage analyses of cannabis dependence, craving, and withdrawal in the San Francisco family study.
Article in American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium.Translational psychiatry · 2016Pooled it
- The genetic aetiology of cannabis use: from twin models to genome-wide association studies and beyond.Translational psychiatry · 2022Review
- The genetic basis of the comorbidity between cannabis use and major depression.Addiction (Abingdon, England) · 2017Article
- Genetic variation in FAAH is associated with cannabis use disorders in a young adult sample of Mexican Americans.Drug and alcohol dependence · 2016Article
- Clinical characteristics of alcohol combined with other substance use disorders in an American Indian community sample.Drug and alcohol dependence · 2016Article
- Psychometric modeling of abuse and dependence symptoms across six illicit substances indicates novel dimensions of misuse.Addictive behaviors · 2016Article
- Childhood maltreatment, stressful life events, and alcohol craving in adult drinkers.Alcoholism, clinical and experimental research · 2014Article
- Measuring historical trauma in an American Indian community sample: contributions of substance dependence, affective disorder, conduct disorder and PTSD.Drug and alcohol dependence · 2013Article
- Lifetime history of traumatic events in an American Indian community sample: heritability and relation to substance dependence, affective disorder, conduct disorder and PTSD.Journal of psychiatric research · 2013Article
- Linkage analysis followed by association show NRG1 associated with cannabis dependence in African Americans.Biological psychiatry · 2012Article
- Genome-wide linkage scan of antisocial behavior, depression, and impulsive substance use in the UCSF family alcoholism study.Psychiatric genetics · 2012Article
- Cytogenetic risks and possible adverse health effects by narcotic substances dependent.International journal of preventive medicine · 2012Article
- The genetics of substance dependence.Annual review of genomics and human genetics · 2012Review
- Linkage analyses of stimulant dependence, craving, and heavy use in American Indians.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2011Article
- Genome-wide scan for self-rating of the effects of alcohol in American Indians.Psychiatric genetics · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Cannabis is the most widely used illicit drug in the United States. There is ample evidence that cannabis use has a heritable component, yet the genes underlying cannabis use disorders are yet to be completely identified. This study's aims were to map susceptibility loci for cannabis use and dependence and two narrower cannabis-related phenotypes of "craving" and "withdrawal" using a family study design. Participants were 2,524 adults participating in the University of California San Francisco (UCSF) Family Alcoholism Study. DSM-IV diagnoses of cannabis dependence, as well as indices of cannabis craving and withdrawal, were obtained using a modified version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Genotypes were determined for a panel of 791 microsatellite polymorphisms. Multipoint variance component LOD scores were obtained using SOLAR. Genome-wide significance for linkage (LOD > 3.0) was not found for the DSM-IV cannabis dependence diagnosis; however, linkage analyses of cannabis "craving" and the cannabis withdrawal symptom of "nervous, tense, restless, or irritable" revealed five sites with LOD scores over 3.0 on chromosomes 1, 3, 6, 7, and 9. These results identify new regions of the genome associated with cannabis use phenotypes as well as corroborate the importance of several chromosome regions highlighted in previous linkage analyses for other substance dependence phenotypes.
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