ArticleThe journal of physiological sciences : JPS2010
The cell boundary theorem: a simple law of the control of cytosolic calcium concentration.
Article in The journal of physiological sciences : JPS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- iPLAScience advances · 2026Article
- Ryanodine Receptor CaActa physiologica (Oxford, England) · 2026Article
- Breaking the link between sarcoplasmic reticulum calcium leakage and mitochondria to counteract unloading-induced muscle atrophy.Pflugers Archiv : European journal of physiology · 2025Article
- Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression.Nature communications · 2025Article
- Cellular calcium homeostasis and regulation of its dynamic perturbation.Quantitative plant biology · 2025Review
- Dual role of the S5 segment in type 1 ryanodine receptor channel gating.Communications biology · 2024Article
- A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice.The Journal of general physiology · 2024Article
- Physiology of intracellular calcium buffering.Physiological reviews · 2023Review
- Cytosolic CaBiophysical reports · 2023Article
- Electrical and Structural Insights into Right Ventricular Outflow Tract Arrhythmogenesis.International journal of molecular sciences · 2023Review
- Article
- A controversial issue: Can mitochondria modulate cytosolic calcium and contraction of skeletal muscle fibers?The Journal of general physiology · 2022Review
- Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2.The Journal of general physiology · 2022Article
- Postdevelopmental knockout of Orai1 improves muscle pathology in a mouse model of Duchenne muscular dystrophy.The Journal of general physiology · 2022Article
- Heat-hypersensitive mutants of ryanodine receptor type 1 revealed by microscopic heating.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Article
- Calcium signaling in intracellular protist parasites.Current opinion in microbiology · 2021Review
- Ryanodine receptor leak triggers fiber CaScience advances · 2021Article
- SOCE in the cardiomyocyte: the secret is in the chambers.Pflugers Archiv : European journal of physiology · 2021Review
- The Orai1 inhibitor BTP2 has multiple effects on Ca2+ handling in skeletal muscle.The Journal of general physiology · 2021Article
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Abstract
Many molecular biological interventions in current use, as well as inheritable disease conditions, modify the intracellular endowment of molecules that bind Ca(2+) or channels and pumps that transfer it to and from intracellular storage organelles. A simple law, named the "cell boundary theorem," states that intracellular alterations cannot directly result in changes in the cytosolic concentration, [Ca(2+)](i), in a true resting state. A demonstration of the validity of this theorem is provided. Several examples are then discussed of interventions or diseases that increase leak of Ca(2+) from storage organelles and result in greater resting [Ca(2+)](i). According to the theorem, the increase in [Ca(2+)](i) cannot be a direct consequence of the greater leak. Its primary cause must be a change of the fluxes at the level of the plasmalemma, caused in turn by the increase in leak through some sort of "store-operated Ca(2+) entry." While the law is discussed in terms of Ca(2+) homeostasis, it applies to any solute that may be transported by the plasma membrane.
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