Trial reportEuropean journal of applied physiology2010
Effects of strength training with eccentric overload on muscle adaptation in male athletes.
Trial report in European journal of applied physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 6 syntheses or guidelines pooled it, 180 citations in OpenAlex.
- The Effects of Advanced Resistance Training Prescription Methods on Strength, Power, Hypertrophy, and Performance Adaptations in Healthy Adults: A Systematic Review and Bayesian Network Meta-analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Acute and Chronic Effects of Accentuated Eccentric Loading vs. Constant-Load Resistance Training: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2026Pooled it
- Accentuated eccentric loading in lower-body resistance training: a systematic review of acute and chronic adaptations on strength, power, and speed outcomes.Frontiers in physiology · 2025Pooled it
- The effect of flywheel training on strength and physical capacities in sporting and healthy populations: An umbrella review.PloS one · 2022Pooled it
- Maximizing Muscle Hypertrophy: A Systematic Review of Advanced Resistance Training Techniques and Methods.International journal of environmental research and public health · 2019Pooled it
- Chronic Adaptations to Eccentric Training: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2017Pooled it
- Balance Training: Toward a Comprehensive Understanding and Application of the Overload Principle in Motor Skill Acquisition.European journal of sport science · 2026Trial
- A Comparative Study of High-Intensity Flywheel Eccentric Training and Traditional Barbell Training on Athletic Performance in Female Basketball Players.Journal of sports science & medicine · 2025Trial
- Flywheel resistance training promotes unique muscle architectural and performance-related adaptations in young adults.European journal of sport science · 2024Trial
- Effects of once- versus twice-weekly eccentric resistance training on muscular function and structure in older adults: a randomised controlled trial.Scientific reports · 2024Trial
- Effects of Eccentric-Oriented Strength Training on Return to Sport Criteria in Late-Stage Anterior Cruciate Ligament (ACL)-Reconstructed Professional Team Sport Players.Medicina (Kaunas, Lithuania) · 2023Trial
- Ipsilateral Lower-to-Upper Limb Cross-Transfer Effect on Muscle Strength, Mechanical Power, and Lean Tissue Mass after Accentuated Eccentric Loading.Medicina (Kaunas, Lithuania) · 2021Trial
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- Effects of eccentric-focused and conventional resistance training on strength and functional capacity of older adults.Age (Dordrecht, Netherlands) · 2015Trial
- Effect of low-level laser therapy on muscle adaptation to knee extensor eccentric training.European journal of applied physiology · 2015Trial
- Early-phase musculoskeletal adaptations to different levels of eccentric resistance after 8 weeks of lower body training.European journal of applied physiology · 2014Trial
- Time course of muscle damage and inflammatory responses to resistance training with eccentric overload in trained individuals.Mediators of inflammation · 2013Trial
- Isokinetic eccentric training is more effective than constant load eccentric training for quadriceps rehabilitation following anterior cruciate ligament reconstruction: a randomized controlled trial.Brazilian journal of physical therapyTrial
- Cross-Education Effects After Submaximal and Supramaximal Accentuated Eccentric Loading on Lean Mass and Function in Women.Journal of functional morphology and kinesiology · 2026Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In classic concentric/eccentric exercise, the same absolute load is applied in concentric and eccentric actions, which infers a smaller relative eccentric load. We compared the effects of 6 weeks of classic concentric/eccentric quadriceps strength training (CON/ECC, 11 subjects) to eccentric overload training (CON/ECC+, 14 subjects) in athletes accustomed to regular strength training. The parameters determined included functional tests, quadriceps and fibre cross-sectional area (CSA), fibre type distribution by ATPase staining, localisation of myosin heavy chain (MHC) isoform mRNAs by situ hybridization and the steady-state levels of 48 marker mRNAs (RT-PCR) in vastus lateralis biopsies taken before and after training. Both training forms had anabolic effects with significant increases in quadriceps CSA, maximal strength, ribosomal RNA content and the levels of mRNAs involved in growth and regeneration. Only the CON/ECC+ training led to significantly increased height in a squat jump test. This was accompanied by significant increases in IIX fibre CSA, in the percentage of type IIA fibres expressing MHC IIx mRNA, in the level of mRNAs preferentially expressed in fast, glycolytic fibres, and in post-exercise capillary lactate. The enhanced eccentric load apparently led to a subtly faster gene expression pattern and induced a shift towards a faster muscle phenotype plus associated adaptations that make a muscle better suited for fast, explosive movements.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.