ArticleJournal of gastrointestinal cancer2009
The Relationships Between Loss of Standard CD44 Expression and Lymph Node, Liver Metastasis in T3 Colorectal Carcinoma.
Article in Journal of gastrointestinal cancer, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- The Prognostic and Clinical Value of CD44 in Colorectal Cancer: A Meta-Analysis.Frontiers in oncology · 2019Pooled it
- Role of CD44 isoforms in epithelial-mesenchymal plasticity and metastasis.Clinical & experimental metastasis · 2022Review
- Extracellular matrix and its therapeutic potential for cancer treatment.Signal transduction and targeted therapy · 2021Review
- Detection of Cancer Stem Cells in Colorectal Cancer: Histopathological and Immunohistochemical Study.Open access Macedonian journal of medical sciences · 2016Article
- Loss of villin immunoexpression in colorectal carcinoma is associated with poor differentiation and survival.ISRN gastroenterology · 2013Article
- CD44 and HCELL: preventing hematogenous metastasis at step 1.FEBS letters · 2011Review
- CD44 and p53 immunoexpression patterns in NF1 neoplasms - indicators of malignancy and infiltration.International journal of clinical and experimental pathology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the present study was to evaluate the standard CD44 (CD44s) expression in colorectal cancer (CRC) with invasion to the subserosal layer (T3), its relationship with clinicopathological characteristics, and its potential metastatic significance. MATERIALS AND
methodsCD44s expression was measured on immunohistochemistry in tumors from 65 patients with primary colorectal carcinomas. CD44s expression was estimated at the deepest invaded area of the tumor in subserosal layer.
resultsCD44s was demonstrated in 35.4% (23/65). CD44s expression showed no significant relationship with the clinicopathological characteristics such as age, gender, tumor location, tumor size, and macroscopic/microscopic classification. However, the CD44s expression showed significantly adverse relationship with lymph node metastasis (p < 0.05) and liver metastasis (p < 0.01), respectively.
conclusionThe loss of CD44s expression in cancer cells in the deepest invaded area is a good marker for predicting potential metastasis to lymph nodes and liver in T3 CRC.
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Registered trials
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